C₁₂H₁₉ClOSiZn

Base Information

• Chemical Name: C₁₂H₁₉ClOSiZn
• CAS No.: 365448-17-5
• Molecular Formula: C₁₂H₁₉ClOSiZn
• Molecular Weight: 308.211
• Mol file: 365448-17-5.mol

Synonyms:C₁₂H₁₉ClOSiZn

Chemical Property of C₁₂H₁₉ClOSiZn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₉ClOSiZn

There total 3 articles about C₁₂H₁₉ClOSiZn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

1-<(tert-butyldimethylsilyl)oxy>-4-chlorobenzene (126644-72-2) → C12H19ClOSiZn (365448-17-5)

Guidance literature:

1-<(tert-butyldimethylsilyl)oxy>-4-chlorobenzene; With lithium 4,4′-di-tert-butylbiphenylide; In tetrahydrofuran; diethyl ether; decane; at -95 ℃; for 0.0833333h; Inert atmosphere; Schlenk technique;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; decane; at -95 - 20 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1055/s-0034-1380697

Reference yield:

t-butyldimethylsilyl-4-bromophenol (67963-68-2) + zinc(II) chloride (7646-85-7,24359-56-6) → C12H19ClOSiZn (365448-17-5)

Guidance literature:

t-butyldimethylsilyl-4-bromophenol; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

zinc(II) chloride; In tetrahydrofuran; at 20 ℃; for 0.666667h; Inert atmosphere;

DOI:10.1021/ja501815p

Reference yield:

{p-[(tert-butyldimethylsilyl)oxy]phenyl}lithium + zinc(II) chloride (7646-85-7,24359-56-6) → C12H19ClOSiZn (365448-17-5)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 0.5h; Glovebox; Inert atmosphere;

DOI:10.1002/anie.201502379

upstream raw materials:

t-butyldimethylsilyl-4-bromophenol

zinc(II) chloride

1-<(tert-butyldimethylsilyl)oxy>-4-chlorobenzene

Downstream raw materials:

(S)-2-(4-((tert-butyldimethylsilyl)oxy)phenyl)-2-fluoro-1,3-diphenylpropan-1-one