(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-1,3-thiazolidine-2,4-dione

Base Information

Chemical Name:(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-1,3-thiazolidine-2,4-dione
CAS No.:1351564-75-4
Molecular Formula:C₂₅H₂₂ClF₃N₄O₃S
Molecular Weight:550.989
Hs Code.:

Synonyms:(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-1,3-thiazolidine-2,4-dione

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Chemical Property of (5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-1,3-thiazolidine-2,4-dione

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Technology Process of (5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-1,3-thiazolidine-2,4-dione

There total 5 articles about (5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-1,3-thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₁₄Cl₂F₃N₃O₂S

: 100243-39-8
3-hydroxypyrrolidine

: 1351564-75-4
(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-1,3-thiazolidine-2,4-dione

Guidance literature:: In N,N-dimethyl-formamide; at 70 ℃; for 1h;

Reference yield:

: 253801-04-6
1H-indazole-5-carbaldehyde

: 1351564-75-4
(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: ammonium acetate; acetic acid / 12 h / 110 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

4: N,N-dimethyl-formamide / 1 h / 70 °C

With ammonium acetate; potassium carbonate; caesium carbonate; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 886496-75-9
1-(bromomethyl)-4-chloro-2-(trifluoromethyl)benzene

: 1351564-75-4
(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-1H-indazol-5-yl}methylidene)-3-{2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl}-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 90 °C

2: ammonium acetate; acetic acid / 12 h / 110 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

4: N,N-dimethyl-formamide / 1 h / 70 °C

With ammonium acetate; potassium carbonate; caesium carbonate; acetic acid; In N,N-dimethyl-formamide;