2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ⁶-[1,2]oxathiol-4-ylamine

Base Information

• Chemical Name: 2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ⁶-[1,2]oxathiol-4-ylamine
• CAS No.: 195370-96-8
• Molecular Formula: C₁₀H₈F₃NO₃S
• Molecular Weight: 279.24

Synonyms:2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ⁶-[1,2]oxathiol-4-ylamine

Chemical Property of 2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ⁶-[1,2]oxathiol-4-ylamine

Chemical Property:

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Technology Process of 2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ⁶-[1,2]oxathiol-4-ylamine

There total 2 articles about 2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ⁶-[1,2]oxathiol-4-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester (195370-91-3) → 2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ6-[1,2]oxathiol-4-ylamine (195370-96-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/jo9707242

Reference yield:

3,3,3-trifluoro-2-hydroxy-2-phenyl-propionitrile (93923-55-8,20445-04-9) → 2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ6-[1,2]oxathiol-4-ylamine (195370-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / pyridine / 48 h / Ambient temperature

2: 71 percent / NaH / tetrahydrofuran / 0.5 h / 0 °C

With sodium hydride; In tetrahydrofuran; pyridine;

DOI:10.1021/jo9707242

Reference yield: 71.0%

2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ6-[1,2]oxathiol-4-ylamine (195370-96-8) → 2,2-Dioxo-5-phenyl-5-trifluoromethyl-2λ6-[1,2]oxathiolan-4-one (195371-03-0)

Guidance literature:

With hydrogenchloride; In methanol; for 2h; Ambient temperature;

DOI:10.1021/jo9707242

upstream raw materials:

Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester

3,3,3-trifluoro-2-hydroxy-2-phenyl-propionitrile

Downstream raw materials:

2,2-Dioxo-5-phenyl-5-trifluoromethyl-2λ⁶-[1,2]oxathiolan-4-one

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