Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester

Base Information

• Chemical Name: Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester
• CAS No.: 195370-91-3
• Molecular Formula: C₁₀H₈F₃NO₃S
• Molecular Weight: 279.24
• Mol file: 195370-91-3.mol

Synonyms:Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester

Chemical Property of Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester

There total 1 articles about Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methanesulfonyl chloride (124-63-0) + 3,3,3-trifluoro-2-hydroxy-2-phenyl-propionitrile (93923-55-8,20445-04-9) → Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester (195370-91-3)

Guidance literature:

In pyridine; for 48h; Ambient temperature;

DOI:10.1021/jo9707242

Reference yield: 71.0%

Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester (195370-91-3) → 2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ6-[1,2]oxathiol-4-ylamine (195370-96-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/jo9707242

Reference yield:

Methanesulfonic acid 1-cyano-2,2,2-trifluoro-1-phenyl-ethyl ester (195370-91-3) → ammonium 4,4,4-trifluoro-2-oxo-3-phenylbutanesulfonate

Guidance literature:

Multi-step reaction with 3 steps

1: 71 percent / NaH / tetrahydrofuran / 0.5 h / 0 °C

2: 71 percent / conc. HCl / methanol / 2 h / Ambient temperature

3: 1.) H₂, 2.) NH₃ / 1.) 10percent Pd/C / 1.) MeOH, 2.5E₅ Pa, room temperature, 8 h, 2.) EtOH, Et₂O

With hydrogenchloride; ammonia; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/jo9707242

upstream raw materials:

methanesulfonyl chloride

3,3,3-trifluoro-2-hydroxy-2-phenyl-propionitrile

Downstream raw materials:

2,2-Dioxo-5-phenyl-5-trifluoromethyl-2,5-dihydro-2λ⁶-[1,2]oxathiol-4-ylamine

2,2-Dioxo-5-phenyl-5-trifluoromethyl-2λ⁶-[1,2]oxathiolan-4-one