2-(2,2,2-trifluoro-acetylamino)-benzoic acid cyclohexyl ester

Base Information

• Chemical Name: 2-(2,2,2-trifluoro-acetylamino)-benzoic acid cyclohexyl ester
• CAS No.: 1028263-34-4
• Molecular Formula: C₁₅H₁₆F₃NO₃
• Molecular Weight: 315.292
• Mol file: 1028263-34-4.mol

Synonyms:2-(2,2,2-trifluoro-acetylamino)-benzoic acid cyclohexyl ester

Chemical Property of 2-(2,2,2-trifluoro-acetylamino)-benzoic acid cyclohexyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(2,2,2-trifluoro-acetylamino)-benzoic acid cyclohexyl ester

There total 2 articles about 2-(2,2,2-trifluoro-acetylamino)-benzoic acid cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(trifluoroacetyl)anthranilic acid (19165-29-8) + cyclohexanol (108-93-0) → 2-(2,2,2-trifluoro-acetylamino)-benzoic acid cyclohexyl ester (1028263-34-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In acetonitrile; at 40 ℃; for 24h;

DOI:10.1016/S0040-4039(00)02327-3

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2-(2,2,2-trifluoro-acetylamino)-benzoic acid cyclohexyl ester (1028263-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / 1 h

2: DMAP; DCC / acetonitrile / 24 h / 40 °C

With dmap; dicyclohexyl-carbodiimide; In acetonitrile;

DOI:10.1016/j.tet.2004.05.024

Reference yield:

2-(2,2,2-trifluoro-acetylamino)-benzoic acid cyclohexyl ester (1028263-34-4) → cyclohexyl 2-aminobenzoate (7779-16-0)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 3h;

DOI:10.1016/S0040-4039(00)02327-3

upstream raw materials:

N-(trifluoroacetyl)anthranilic acid

cyclohexanol

anthranilic acid

Downstream raw materials:

cyclohexyl 2-aminobenzoate