benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)pyrrolidine-1-carboxylate
CAS No.:479234-55-4
Molecular Formula:C₁₉H₂₇N₃O₂S
Molecular Weight:361.508
Hs Code.:

Synonyms:benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)pyrrolidine-1-carboxylate

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Chemical Property of benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)pyrrolidine-1-carboxylate

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Technology Process of benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)pyrrolidine-1-carboxylate

There total 7 articles about benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonyl)pyrrolidine-1-carboxylate

: 479234-55-4
benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)pyrrolidine-1-carboxylate

Guidance literature:: With Lawessons reagent; In chlorobenzene; at 150 ℃; for 2h; Microwave irradiation; Inert atmosphere;
DOI:10.1016/j.tetlet.2014.06.022

Reference yield:

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 479234-55-4
benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / water soluble carbodiimide hydrochloride; HOBt; Et₃N / CH₂Cl₂

2: 67 percent / Lawesson's reagent / toluene / 85 °C

3: HCl / dioxane

4: NaCNBH₃; AcOH / methanol

With Lawessons reagent; hydrogenchloride; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2004.04.107

Reference yield:

: 112275-50-0
tert-butyl 1,4-diazepine-1-carboxylate

: 479234-55-4
benzyl (S)-2-(4-methyl-1,4-diazepane-1-carbonothioyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / water soluble carbodiimide hydrochloride; HOBt; Et₃N / CH₂Cl₂

2: 67 percent / Lawesson's reagent / toluene / 85 °C

3: HCl / dioxane

4: NaCNBH₃; AcOH / methanol

With Lawessons reagent; hydrogenchloride; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2004.04.107