(N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide)

Base Information

Chemical Name:(N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide)
CAS No.:1621999-82-3
Molecular Formula:C₂₂H₂₁F₃N₆O₂
Molecular Weight:458.443
Hs Code.:2933998090

Synonyms:(N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide)

Suppliers and Price of (N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
CC-90003 99.84%
50mg
$ 740.00

ChemScene
CC-90003 99.84%
25mg
$ 450.00

ChemScene
CC-90003 99.84%
10mg
$ 240.00

ChemScene
CC-90003 99.84%
5mg
$ 140.00

ChemScene
CC-90003 99.84%
100mg
$ 1300.00

Apolloscientific
N-(2-((2-((2-Methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide
50mg
$ 943.00

Apolloscientific
N-(2-((2-((2-Methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide
5mg
$ 189.00

Total 4 raw suppliers

Chemical Property of (N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide)

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

CC-90003 99.84% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide)

There total 14 articles about (N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: tert-butyl 4-((2-acrylamido-4-methylphenyl(amino))-5-(trifluoromethyl)pyrimidin-2-yl)-(2-methoxy-5-methylpyridin-4-yl)carbamate

: 1621999-82-3
(N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide)

Guidance literature:: tert-butyl 4-((2-acrylamido-4-methylphenyl(amino))-5-(trifluoromethyl)pyrimidin-2-yl)-(2-methoxy-5-methylpyridin-4-yl)carbamate; With sulfuric acid; In methanol; at 20 - 45 ℃; for 4h;

With triethylamine; In methanol; at 20 - 30 ℃; for 4h;

Reference yield:

: 1260663-96-4
(2-methoxy-5-methylpyridin-4-amine)

: N-(2-(2-chloro-5-(trifluoromethyl)pyrimidin-4-ylamino)-5-methylphenyl)acrylamide

: 1621999-82-3
(N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide)

Guidance literature:: With toluene-4-sulfonic acid; In 1,4-dioxane; at 95 ℃; for 16h;

Reference yield:

: N-(2-amino-5-methylphenyl)acrylamide

: 1621999-82-3
(N-(2-((2-((2-methoxy-5-methylpyridin-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-5-methylphenyl)acrylamide)

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl acetamide / 1 h / 60 °C

2: toluene-4-sulfonic acid / 1,4-dioxane / 16 h / 95 °C

With potassium carbonate; toluene-4-sulfonic acid; In 1,4-dioxane; N,N-dimethyl acetamide;