5-chloro-3-phenyl-2-(4-{[4-(5-pyrimidin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

Base Information

Chemical Name:5-chloro-3-phenyl-2-(4-{[4-(5-pyrimidin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine
CAS No.:917363-99-6
Molecular Formula:C₃₂H₂₇ClN₈
Molecular Weight:559.073
Hs Code.:

Synonyms:5-chloro-3-phenyl-2-(4-{[4-(5-pyrimidin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

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Chemical Property of 5-chloro-3-phenyl-2-(4-{[4-(5-pyrimidin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

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Technology Process of 5-chloro-3-phenyl-2-(4-{[4-(5-pyrimidin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

There total 11 articles about 5-chloro-3-phenyl-2-(4-{[4-(5-pyrimidin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 917363-90-7
4-(5-chloro-3-phenyl-[1,6]naphthyridin-2-yl)-benzaldehyde

: 1240108-75-1
2-(3-piperidin-4-yl-1H-1,2,4-triazol-5-yl)pyrimidine hydrochloric acid salt

: 917363-99-6
5-chloro-3-phenyl-2-(4-{[4-(5-pyrimidin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃;

Reference yield:

: 234108-73-7
(2-chloro-pyridin-4-yl)-carbamic acid tert-butyl ester

: 917363-99-6
5-chloro-3-phenyl-2-(4-{[4-(5-pyrimidin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; N,N-dimethyl-formamide; pentane / 5 h / -70 - 20 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Heating / reflux

3.1: hydrogenchloride; water / 1,4-dioxane / 3 h / 0 - 20 °C

3.2: pH > 7

4.1: sodium tris(acetoxy)borohydride; acetic acid; triethylamine / 1-methyl-pyrrolidin-2-one / 20 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; pentane;

Reference yield:

: 14432-12-3
4-Amino-2-chloropyridine

: 917363-99-6
5-chloro-3-phenyl-2-(4-{[4-(5-pyrimidin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)-1,6-naphthyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 0 - 20 °C

2.1: tetrahydrofuran; N,N-dimethyl-formamide; pentane / 5 h / -70 - 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Heating / reflux

4.1: hydrogenchloride; water / 1,4-dioxane / 3 h / 0 - 20 °C

4.2: pH > 7

5.1: sodium tris(acetoxy)borohydride; acetic acid; triethylamine / 1-methyl-pyrrolidin-2-one / 20 °C

With hydrogenchloride; water; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; pentane;