Vancomycin hydrochloride

Base Information

• Chemical Name: Vancomycin hydrochloride
• CAS No.: 1404-93-9
• Molecular Formula: C66H75Cl2N9O24.HCl
• Molecular Weight: 1485.73
• Hs Code.: 29419090
• European Community (EC) Number: 604-193-8
• NSC Number: 717112
• UNII: 71WO621TJD
• DSSTox Substance ID: DTXSID90891868
• Wikidata: Q27265994
• NCI Thesaurus Code: C65207
• RXCUI: 66955
• ChEMBL ID: CHEMBL1200628,CHEMBL3747636
• Mol file: 1404-93-9.mol

Synonyms:AB-Vancomycin;Diatracin;Hydrochloride, Vancomycin;Sulfate, Vancomycin;Vanco Azupharma;VANCO-cell;Vanco-saar;Vancocin;Vancocin HCl;Vancocine;Vancomicina Abbott;Vancomicina Chiesi;Vancomicina Combino Phar;Vancomicina Norman;Vancomycin;Vancomycin Hexal;Vancomycin Hydrochloride;Vancomycin Lilly;Vancomycin Phosphate (1:2);Vancomycin Phosphate (1:2), Decahydrate;Vancomycin Sulfate;Vancomycin-ratiopharm;Vancomycine Dakota

Chemical Property of Vancomycin hydrochloride

Chemical Property:

• Appearance/Colour: off white powder
• Melting Point: >190°C (dec.)
• Flash Point: 87℃
• PSA: 530.49000
• Density: 1.657 g/cm³
• LogP: 4.73460
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Solubility.: H2O: 50 mg/mL, clear, yellow
• Water Solubility.: Soluble in water. Slightly soluble in methanol, ethanol and dimethylsulfoxide.
• Hydrogen Bond Donor Count: 20
• Hydrogen Bond Acceptor Count: 26
• Rotatable Bond Count: 13
• Exact Mass: 1483.406877
• Heavy Atom Count: 102
• Complexity: 2960

Purity/Quality:

99% ^*data from raw suppliers

Vancomycin hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 43-42
• Safety Statements: 36/37-24/25-22-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1C(C(CC(O1)OC2C(C(C(OC2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)C(C(C(=O)NC(C(=O)NC5C(=O)NC7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)C(NC(=O)C(C(C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)C(CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl
• Isomeric SMILES: C[C@H]1[C@H]([C@@](C[C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2OC3=C4C=C5C=C3OC6=C(C=C(C=C6)[C@H]([C@H](C(=O)N[C@H](C(=O)N[C@H]5C(=O)N[C@@H]7C8=CC(=C(C=C8)O)C9=C(C=C(C=C9O)O)[C@H](NC(=O)[C@H]([C@@H](C1=CC(=C(O4)C=C1)Cl)O)NC7=O)C(=O)O)CC(=O)N)NC(=O)[C@@H](CC(C)C)NC)O)Cl)CO)O)O)(C)N)O.Cl
• Recent ClinicalTrials: Intramedullary Calcium Sulfate Antibiotic Depot
• Recent EU Clinical Trials: A phase III, multicenter, randomized, double-blind clinical trial to evaluate the efficacy and safety of oral vancomycin versus placebo in preventing relapse of Clostridioides difficile infection in patients receiving systemic antibiotic therapy (PREVAN-ICD study).
• Uses: It has a narrow antimicrobial spectrum which is mainly against Gram-positive bacteria. It is a kind of narrow-spectrum antibiotics only effective in treating gram-positive bacteria, such as Streptococcus pneumoniae, Neisseria gonorrhoeae and enterococci; etc which are all sensitive to this drug. Staphylococcus aureus is particularly sensitive to this product. Its mechanism of action is inhibition of bacterial cell wall synthesis; it mainly binds to the bacterial cell wall and leaving some kinds of amino acids being unable to enter into the glycopeptides of the cell wall. Amphoteric glycopeptide antibiotic produced by Streptomyces orientalis discovered in soil. Inhibits bacterial cell wall synthesis by binding to peptidoglycan. Antibacterial. Vancomycin hydrochloride is the salt of a glycopeptide antibiotic isolated from Amycolatopsis orientalis in 1956. Vancomycin exhibits potent activity against Gram positive bacteria and is highly effective against MRSA in vitro and in vivo. Vancomycin interferes with cell wall synthesis by binding to D-alanine-D-alanine residues. Vancomycin Hydrochloride is an antibiotic used against gram-positive bacterial strains.
• Description: Vancomycin is a glycopeptide antibiotic identified for its utility in the treatment of gram-positive bacteria, including penicillin-resistant staphylococci. It acts by binding to bacterial cell wall protein precursors, interfering with continuing protein synthesis. Vancomycin resistance in staphylococcal species has recently emerged as a clinical issue.