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| CAS No.: | 1404-93-9 |
|---|---|
| Name: | Vancomycin hydrochloride |
| Molecular Structure: | |
|
|
|
| Formula: | C66H75Cl2N9O24.HCl |
| Molecular Weight: | 1485.73 |
| Synonyms: | Lyphocin;Meek;Vancocinehydrochloride;Vancocyn;Vancor; |
| EINECS: | 215-772-6 |
| Density: | 1.657 g/cm3 |
| Melting Point: | >190°C (dec.) |
| Flash Point: | 87℃ |
| Solubility: | 50 mg/mL in water,clear, yellow |
| Appearance: | off white powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 43 |
| Safety: | 36/37-24/25-22-36 |
| PSA: | 530.49000 |
| LogP: | 4.73460 |
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Chemistry
Product Name: Vancomycin hydrochloride
Molecular Structure of Vancocin hydrochloride (CAS NO.1404-93-9):
Molecular Formula: C66H75Cl2N9O24
Molecular Weight: 1449.2536
Synonyms of Vancocin hydrochloride (CAS NO.1404-93-9): Vancomycin hydrochloride [USAN] ; (3S-(3R*,6S*(S*),7S*,22S*,23R*,26R*,36S*,38aS*))-3-(2-Amino-2-oxoethyl)-44-((2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyl)oxy)-10,19-dichloro-2,3,4,5,6,7,23,24,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-((4-methyl-2-(methylamino)-1-oxopentyl)amino)-2,5,24,38,39-pentaoxo-22H-8,11:18,21-dietheno-23,36-(iminomethano)-13,16:31,35-dimetheno-1H,16H-(1,6,9)oxadiazacyclohexadecino(4,5-m)(10,2,16)benzoxadiazacyclotetracosine-26-carboxylic acid, monohydrochloride ; UNII-71WO621TJD ; Vancocin hydrochloride ; Vancocin hydrochloride in plastic container ; Vancocine hydrochloride ; Vancoled ; Vancomycin HCl ; Vancomycin monohydrochloride ; Vancor
CAS NO: 1404-93-9
Classification Code: Antibacterial ; Drug / Therapeutic Agent ; Human Data ; Reproductive Effect
Index of Refraction: 1.734
Molar Refractivity: 350.83 cm3
Molar Volume: 874.6 cm3
Surface Tension: 105.1 dyne/cm
Density of Vancocin hydrochloride (CAS NO.1404-93-9): 1.65 g/cm3
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | intravenous | 27500ug/kg/10 (27.5mg/kg) | VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE" | Clinical Pediatrics Vol. 23, Pg. 416, 1984. |
| guinea pig | LD50 | intraperitoneal | 737mg/kg (737mg/kg) | KIDNEY, URETER, AND BLADDER: HEMATURIA | Antibiotics Annual. Vol. 4, Pg. 75, 1956/1957. |
| man | LDLo | intravenous | 43mg/kg/2W-I (43mg/kg) | BLOOD: AGRANULOCYTOSIS | American Journal of Medicine. Vol. 81, Pg. 1059, 1986. |
| man | TDLo | intravenous | 1429ug/kg/10- (1.429mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | Mayo Clinic Proceedings. Vol. 61, Pg. 721, 1986. |
| mouse | LD50 | intraperitoneal | 1734mg/kg (1734mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981. | |
| mouse | LD50 | intravenous | 489mg/kg (489mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981. | |
| mouse | LD50 | oral | > 5gm/kg (5000mg/kg) | Antibiotics Annual. Vol. 4, Pg. 75, 1956/1957. | |
| mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | Antibiotics Annual. Vol. 4, Pg. 75, 1956/1957. |
| rat | LD50 | intraperitoneal | 2218mg/kg (2218mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981. | |
| rat | LD50 | intravenous | 319mg/kg (319mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 933, 1981. | |
| rat | LD50 | oral | > 10gm/kg (10000mg/kg) | Drugs in Japan Vol. 6, Pg. 597, 1982. | |
| women | TDLo | intraperitoneal | 40mg/kg (40mg/kg) | GASTROINTESTINAL: PERITONITIS BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT | American Journal of Kidney Diseases. Vol. 17, Pg. 76, 1991. |
| women | TDLo | intravenous | 20mg/kg (20mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) | Annals of Internal Medicine. Vol. 101, Pg. 880, 1984. |
Safety Profile
Poison by intravenous route. Moderately toxic by intraperitoneal routes. Human systemic effects by intravenous route: cardiac arrythmias, blood pressure lowering, and allergic dermatitis. When heated to decomposition it emits toxic fumes of NOx and HCl.
Hazard Codes of Vancocin hydrochloride (CAS NO.1404-93-9): 
Xi
Risk Statements: 43
R43: May cause sensitization by skin contact
Safety Statements: 36/37-24/25-22-36
S36/37: Wear suitable protective clothing and gloves
S24/25: Avoid contact with skin and eyes
S22: Do not breathe dust
S36: Wear suitable protective clothing
WGK Germany: 2
RTECS: YW4380000