3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-methoxyethoxy)-2,6-difluorobenzamide

Base Information

Chemical Name:3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-methoxyethoxy)-2,6-difluorobenzamide
CAS No.:1403881-57-1
Molecular Formula:C₂₀H₁₄BrF₅N₂O₄
Molecular Weight:521.238
Hs Code.:

Synonyms:3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-methoxyethoxy)-2,6-difluorobenzamide

Suppliers and Price of 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-methoxyethoxy)-2,6-difluorobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-methoxyethoxy)-2,6-difluorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-methoxyethoxy)-2,6-difluorobenzamide

There total 6 articles about 3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-methoxyethoxy)-2,6-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1403880-91-0
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-hydroxyethoxy)-2,6-difluorobenzamide

: 74-88-4
methyl iodide

: 1403881-57-1
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-methoxyethoxy)-2,6-difluorobenzamide

Guidance literature:: With silver(l) oxide; In acetonitrile; at 20 ℃;

Reference yield:

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403881-57-1
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-methoxyethoxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 8 steps

1: 2 h / 130 °C

2: sodium tetrahydroborate / methanol / 2 h / Cooling with ice; Reflux

3: triethylamine / dichloromethane / 20 °C / Cooling with ice

4: N-Bromosuccinimide; acetic acid / 20 °C

5: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

6: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

7: potassium carbonate / methanol / 1 h / 20 °C

8: silver(l) oxide / acetonitrile / 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; triethylamine; silver(l) oxide; In methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1403883-97-5
2-(4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)ethyl acetate

: 1403881-57-1
3-(1-(5-bromo-4-(4-(trifluoromethyl)phenyl)oxazol-2-yl)-2-methoxyethoxy)-2,6-difluorobenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide; acetic acid / 20 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 80 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

4: potassium carbonate / methanol / 1 h / 20 °C

5: silver(l) oxide / acetonitrile / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; acetic acid; silver(l) oxide; In methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;