tert-butyl (1-cyclohexyl-5-oxo-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

Base Information

Chemical Name:tert-butyl (1-cyclohexyl-5-oxo-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate
CAS No.:1228935-10-1
Molecular Formula:C₂₂H₂₈N₄O₃
Molecular Weight:396.489
Hs Code.:

Synonyms:tert-butyl (1-cyclohexyl-5-oxo-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

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Chemical Property of tert-butyl (1-cyclohexyl-5-oxo-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

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Technology Process of tert-butyl (1-cyclohexyl-5-oxo-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

There total 1 articles about tert-butyl (1-cyclohexyl-5-oxo-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 1-cyclohexyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1228935-10-1
tert-butyl (1-cyclohexyl-5-oxo-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

Guidance literature:: 1-cyclohexyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one; With sodium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; at 20 ℃; Inert atmosphere; Cooling with ice;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; at 20 ℃; for 2h; Inert atmosphere;

Reference yield: 18.0%

: 1228935-10-1
tert-butyl (1-cyclohexyl-5-oxo-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

: 174180-42-8
2-methyl-2-propanyl 3-(bromomethyl)-1H-indazole-1-carboxylate

: 1228935-11-2
tert-butyl 3-{[6-(2-tert-butoxy-2-oxoethyl)-1-cyclohexyl-5-oxo-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl]methyl}-1H-indazole-1-carboxylate

Guidance literature:: tert-butyl (1-cyclohexyl-5-oxo-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.25h;

2-methyl-2-propanyl 3-(bromomethyl)-1H-indazole-1-carboxylate; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 1228935-10-1
tert-butyl (1-cyclohexyl-5-oxo-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl)acetate

: 1228935-12-3
1-cyclohexyl-5,6-dihydro-4-(1H-indazol-3-ylmethyl)-5-oxo-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine-6-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;