1-cyclohexyl-4-(1H-indazol-3-ylmethyl)-6-{2-oxo-2-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethyl}-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

Base Information

Chemical Name:1-cyclohexyl-4-(1H-indazol-3-ylmethyl)-6-{2-oxo-2-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethyl}-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one
CAS No.:1228934-40-4
Molecular Formula:C₃₇H₄₀N₈O₂
Molecular Weight:628.777
Hs Code.:

Synonyms:1-cyclohexyl-4-(1H-indazol-3-ylmethyl)-6-{2-oxo-2-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethyl}-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

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Chemical Property of 1-cyclohexyl-4-(1H-indazol-3-ylmethyl)-6-{2-oxo-2-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethyl}-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

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Technology Process of 1-cyclohexyl-4-(1H-indazol-3-ylmethyl)-6-{2-oxo-2-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethyl}-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

There total 4 articles about 1-cyclohexyl-4-(1H-indazol-3-ylmethyl)-6-{2-oxo-2-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethyl}-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 526183-26-6
2-piperidin-2-ylmethylpyridine

: 1228935-12-3
1-cyclohexyl-5,6-dihydro-4-(1H-indazol-3-ylmethyl)-5-oxo-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine-6-acetic acid

: 1228934-40-4
1-cyclohexyl-4-(1H-indazol-3-ylmethyl)-6-{2-oxo-2-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethyl}-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃;

Reference yield:

: 1228935-11-2
tert-butyl 3-{[6-(2-tert-butoxy-2-oxoethyl)-1-cyclohexyl-5-oxo-5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-4-yl]methyl}-1H-indazole-1-carboxylate

: 1228934-40-4
1-cyclohexyl-4-(1H-indazol-3-ylmethyl)-6-{2-oxo-2-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethyl}-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1-cyclohexyl-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

: 1228934-40-4
1-cyclohexyl-4-(1H-indazol-3-ylmethyl)-6-{2-oxo-2-[2-(pyridin-2-ylmethyl)piperidin-1-yl]ethyl}-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-5(6H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide; toluene / 20 °C / Inert atmosphere; Cooling with ice

1.2: 2 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2.2: 20 °C

3.1: trifluoroacetic acid / dichloromethane / 15 h / 20 °C

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

With sodium hexamethyldisilazane; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;