(S)-(+)-1-Phenyl-1,2-ethanediol

Base Information

Chemical Name:(S)-(+)-1-Phenyl-1,2-ethanediol
CAS No.:25779-13-9
Molecular Formula:C8H10O2
Molecular Weight:138.166
Hs Code.:29062900
Mol file:25779-13-9.mol

Synonyms:1,2-Ethanediol,1-phenyl-, (S)-;1,2-Ethanediol, 1-phenyl-, (S)-(+)- (8CI);(+)-(1S)-1-Phenyl-1,2-ethanediol;(+)-1-Phenyl-1,2-ethanediol;(+)-1-Phenylethylene glycol;(+)-Phenyl glycol;(+)-Phenylethane-1,2-diol;(+)-Phenylethylene glycol;(+)-Styrene glycol;(1S)-1-(Phenyl)ethane-1,2-diol;(2S)-2-Phenylethane-1,2-diol;(S)-(+)-Phenyl-1,2-ethanediol;(S)-1-Phenyl-1,2-ethanediol;(S)-1-Phenyl-2-hydroxyethanol;(S)-Phenylethane-1,2-diol;(S)-Styrene glycol;

Suppliers and Price of (S)-(+)-1-Phenyl-1,2-ethanediol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-StyreneGlycol
25g
$ 1190.00

TCI Chemical
(S)-(+)-1-Phenylethane-1,2-diol >98.0%(GC)
1g
$ 72.00

TCI Chemical
(S)-(+)-1-Phenylethane-1,2-diol >98.0%(GC)
5g
$ 214.00

SynQuest Laboratories
S-(+)-1-Phenyl-1,2-ethanediol
5 g
$ 100.00

Sigma-Aldrich
(S)-(+)-1-Phenyl-1,2-ethanediol 99%
1g
$ 122.00

Sigma-Aldrich
(S)-(+)-1-Phenyl-1,2-ethanediol purum, ≥98.0% (sum of enantiomers, HPLC)
5g
$ 335.00

Medical Isotopes, Inc.
(S)-StyreneGlycol
25 g
$ 2200.00

Medical Isotopes, Inc.
(S)-StyreneGlycol
2.5 g
$ 650.00

Frontier Specialty Chemicals
(S)-(+)-1-Phenyl-1,2-ethanediol 98%
5g
$ 236.00

Frontier Specialty Chemicals
(S)-(+)-1-Phenyl-1,2-ethanediol 98%
1g
$ 59.00

Total 89 raw suppliers

Chemical Property of (S)-(+)-1-Phenyl-1,2-ethanediol

Chemical Property:

Appearance/Colour:white to light yellow crystal powder
Vapor Pressure:0.00278mmHg at 25°C
Melting Point:64-67 °C(lit.)
Refractive Index:40 ° (C=3, H2O)
Boiling Point:273.5 °C at 760 mmHg
PKA:13.61±0.20(Predicted)
Flash Point:145.8 °C
PSA：40.46000
Density:1.17 g/cm³
LogP:0.71230
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightly), Methanol (Slightly)
Water Solubility.:soluble

Purity/Quality:

99% ^*data from raw suppliers

(S)-StyreneGlycol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi, T
Hazard Codes:Xi,T
Statements: 23/24/25-36/37/38
Safety Statements: 24/25-45-36/37/39-26

MSDS Files:: SDS file from LookChem

Useful:

General Description (S)-(+)-1-Phenyl-1,2-ethanediol (PED) is a valuable chiral building block widely used in specialty chemical industries, particularly for the synthesis of optically active compounds. It can be efficiently produced via biocatalytic reduction of 2-hydroxyacetophenone (2-HAP) using engineered microbial systems, such as recombinant *Pichia pastoris* coexpressing carbonyl reductase and glucose 6-phosphate dehydrogenase, or *E. coli* BL21(DE3) harboring mut-AcCR and GDH. These methods enhance enantioselectivity and yield, making (S)-PED a practical intermediate for pharmaceuticals and asymmetric catalysis. Additionally, (S)-PED and its derivatives have applications in enantioselective synthesis, such as serving as chiral ligands or auxiliaries in Diels-Alder reactions.

Technology Process of (S)-(+)-1-Phenyl-1,2-ethanediol

There total 190 articles about (S)-(+)-1-Phenyl-1,2-ethanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6
styrene

: 96-09-3
styrene oxide

: 16355-00-3
(R)-1-phenyl-1,2-ethanediol

: 25779-13-9
(S)-1-phenyl-1,2-ethanediol

Guidance literature:: With styrene monooxygenase; In Hexadecane; for 24h; optical yield given as %ee; aq. buffer;
DOI:10.1039/b820889a

Reference yield: 95.0%

: 582-24-1
1-phenyl-2-hydroxyethanone

: 16355-00-3
(R)-1-phenyl-1,2-ethanediol

: 25779-13-9
(S)-1-phenyl-1,2-ethanediol

Guidance literature:: With cobalt(II) acetate; C₃₁H₃₁N₂OP; In tetrahydrofuran; at 25 ℃; for 1h; Reagent/catalyst; Inert atmosphere;

Reference yield: 93.8%

: 96-09-3
styrene oxide

: 16355-00-3
(R)-1-phenyl-1,2-ethanediol

: 25779-13-9
(S)-1-phenyl-1,2-ethanediol

Guidance literature:: With Escherichia coli Rosetta(DE₃)/epoxide hydrolase from Glycine max wet cells; In aq. phosphate buffer; at 25 ℃; pH=7; enantioselective reaction; Catalytic behavior; Microbiological reaction; Resolution of racemate; Enzymatic reaction;
DOI:10.1016/j.ijbiomac.2020.08.011