N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine

Base Information

• Chemical Name: N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine
• CAS No.: 269716-58-7
• Molecular Formula: C₄₉H₄₄FN₅O₅
• Molecular Weight: 801.917

Synonyms:N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine

Chemical Property of N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine

Chemical Property:

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Technology Process of N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine

There total 6 articles about N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.7%

N2-(p-anisyldiphenylmethyl)-9-<<(p-anisyldiphenylmethoxy)-3-(p-toluenesulfonyloxy)-2-propoxy>methyl>-guanine (103024-80-2) → N2-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine (269716-58-7)

Guidance literature:

With potassium fluoride; [2.2.2]cryptande; In acetonitrile;

DOI:10.1016/j.bmcl.2003.09.010

Reference yield:

2-amino-1,9-dihydro-6H-purin-6-one (73-40-5) → N2-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine (269716-58-7)

Guidance literature:

Multi-step reaction with 6 steps

1: (NH₄)2SO₄

2: Bu₄NF / tetrahydrofuran

3: cyclohexene / Pd / ethanol

4: DMAP; Et₃N / dimethylformamide

5: pyridine

6: potassium fluoride; Kryptofix 2.2.2 / acetonitrile

With pyridine; dmap; ammonium sulfate; potassium fluoride; tetrabutyl ammonium fluoride; triethylamine; [2.2.2]cryptande; cyclohexene; palladium; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/jlcr.661

Reference yield:

9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine (82410-31-9) → N2-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine (269716-58-7)

Guidance literature:

Multi-step reaction with 4 steps

1: cyclohexene / Pd / ethanol

2: DMAP; Et₃N / dimethylformamide

3: pyridine

4: potassium fluoride; Kryptofix 2.2.2 / acetonitrile

With pyridine; dmap; potassium fluoride; triethylamine; [2.2.2]cryptande; cyclohexene; palladium; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/jlcr.661

upstream raw materials:

N²-(p-anisyldiphenylmethyl)-9-<<(p-anisyldiphenylmethoxy)-3-(p-toluenesulfonyloxy)-2-propoxy>methyl>-guanine

2-amino-1,9-dihydro-6H-purin-6-one

ganciclovir

9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine

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