103024-80-2

Upstream product

• 88110-86-5 9-[({1-hydroxy-3-[(4-methoxyphenyl)-diphenylmethoxy]propan-2-yl}oxy)methyl]-2-{[(4-methoxyphenyl)diphenylmethyl]amino}-6,9-dihydro-1H-purin-6-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 14470-28-1 mono-4-methoxytrityl chloride 
• 18602-85-2 2,6,9-tris(trimethylsilyl)guanine 
• 82410-31-9 9-<<2-(benzyloxy)-1-<(benzyloxy)methyl>ethoxy>methyl>guanine 
• 82410-32-0 ganciclovir 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 

Downstream Products

• 269716-58-7 N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-fluoro-2-propoxy]methyl]guanine 
• 718633-32-0 N¹-methyl-N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethyl)-3-fluoro-2-propoxy]-methyl]guanine 
• 718633-30-8 N¹-methyl-N²-(p-anisyldiphenylmethyl)-9-[[1-(p-anisyldiphenylmethoxy)-3-(p-toluene-sulfonyloxy)-2-propoxy]methyl]guanine 
• 103024-81-3 N²-(p-anisyldiphenylmethyl)-9-<<1-(p-anisyldiphenylmethoxy)-3-azido-2-propoxy>methyl>guanine 

Relevant academic research and scientific papers

Efficient synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG)

A new, high radiochemical yield synthesis of [18F]FHBG and [18F]FHPG, the most popular imaging agents currently in use for monitoring gene therapy using positron emission tomography (PET), is reported in this work. Protection of sens

An Improved Total Synthesis of PET HSV-tk Gene Expression Imaging Agent 9-[(3-[18F]Fluoro-1-hydroxy-2-propoxy)methyl]guanine ([ 18F]FHPG)

An improved total synthesis of [18F]FHPG starting from 1,3-dibenzyloxy-2-propanol and guanine has been developed. [18F]FHPG was prepared by nucleophilic substitution of the appropriate precursor with [18F]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified Silica Sep-Pak solid-phase extraction (SPE) method in 10-15% radiochemical yield, and 70 min synthesis time from end of bombardment (EOB).

Novel radiosynthesis of PET HSV-tk gene reporter probes [ 18F]FHPG and [18F]FHBG employing dual Sep-Pak SPE techniques

Positron emission tomography (PET) herpes simplex virus thymidine kinase (HSV-tk) gene reporter probes 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy) methyl]guanine ([18F]FHPG) and 9-(4-[18F]fluoro-3- hydroxymethylbutyl)guanine ([18F]FHBG) were prepared by nucleophilic substitution of the appropriate tosylated precursors with [18F]KF/ Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified dual Silica Sep-Pak solid-phase extraction (SPE) method in 15-30% radiochemical yield.