2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid

Base Information

• Chemical Name: 2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid
• CAS No.: 66338-96-3
• Molecular Formula: C5H5N3O3S
• Molecular Weight: 187.17
• Hs Code.: 2934.90
• Mol file: 66338-96-3.mol

Synonyms:4-Thiazoleaceticacid, 2-amino-a-(hydroxyimino)-,(Z)-;(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic acid;(Z)-2-Amino-a-(hydroxyimino)-4-thiazoleaceticacid;

Chemical Property of 2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid

Chemical Property:

• Appearance/Colour: yellow crystalline
• Vapor Pressure: 1.82E-12mmHg at 25°C
• Melting Point: 190-192 °C
• Refractive Index: 1.798
• Boiling Point: 539.4 °C at 760 mmHg
• PKA: 10.37±0.70(Predicted)
• Flash Point: 280 °C
• PSA: 137.04000
• Density: 1.92 g/cm³
• LogP: 0.56940
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility.: DMSO (Slightly, Heated)

Purity/Quality:

99% ^*data from raw suppliers

(Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (Z)-2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetic Acid?can be used to synthesize cephalosporin derivatives and β-lactam antibiotics.

Technology Process of 2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid

There total 3 articles about 2-(2-Aminothiazole-4-yl)-2-hydroxyiminoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-ethoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetic acid (68401-22-9) → 2-(2-Amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetic acid (66338-96-3)

Guidance literature:

With sodium hydroxide; In water; at 15 - 20 ℃;

DOI:10.1016/j.poly.2014.08.034

Reference yield:

(Z)-ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate (64485-82-1) → 2-(2-Amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetic acid (66338-96-3)

Guidance literature:

With sodium hydroxide; In ethanol; at 45 ℃; for 0.5h;

DOI:10.1016/0040-4020(78)89034-6

Reference yield:

→ 2-(2-Amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetic acid (66338-96-3)

Guidance literature:

upstream raw materials:

(Z)-ethyl 2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetate

2-ethoxyimino-2-(2-amino-1,3-thiazol-4-yl)acetic acid

Downstream raw materials:

(Z)-2-(trityloxyimino)-2-(2-tritylamino-4-thiazolyl)acetic acid

(Z)-2-(2-aminothiazol-4-yl)-N-(2-hydroxyethyl)-2-(hydroxyimino)acetamide