4-[2,5-dioxo-4-(4-hydroxyphenyl)-4-methyl-3-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile

Base Information

• Chemical Name: 4-[2,5-dioxo-4-(4-hydroxyphenyl)-4-methyl-3-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile
• CAS No.: 959690-11-0
• Molecular Formula: C₂₁H₁₄F₃N₃O₃
• Molecular Weight: 413.356
• Mol file: 959690-11-0.mol

Synonyms:4-[2,5-dioxo-4-(4-hydroxyphenyl)-4-methyl-3-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile

Chemical Property of 4-[2,5-dioxo-4-(4-hydroxyphenyl)-4-methyl-3-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2,5-dioxo-4-(4-hydroxyphenyl)-4-methyl-3-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile

There total 6 articles about 4-[2,5-dioxo-4-(4-hydroxyphenyl)-4-methyl-3-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methyl 2-(4-hydroxyphenyl)-2-(2-propynyl)aminopropionate (959694-49-6) + 4-isocyanato-2-(trifluoromethyl)benzonitrile (143782-18-7) → 4-[2,5-dioxo-4-(4-hydroxyphenyl)-4-methyl-3-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile (959690-11-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

Reference yield:

2-(4-Hydroxy-phenyl)-propionic acid (938-96-5) → 4-[2,5-dioxo-4-(4-hydroxyphenyl)-4-methyl-3-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile (959690-11-0)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / 3.5 h / 0 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran / 0 °C / Inert atmosphere

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 7 h / Inert atmosphere; Reflux

4: tetrahydrofuran; ethanol / 0.5 h / 20 °C / Inert atmosphere

5: tetrahydrofuran / 6 h / 20 °C / Inert atmosphere; Reflux

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrahydrofuran; tetrachloromethane; ethanol;

DOI:10.1021/jm300249m

Reference yield:

methyl 2-(4-hydroxyphenyl)propanoate (65784-33-0) → 4-[2,5-dioxo-4-(4-hydroxyphenyl)-4-methyl-3-(2-propynyl)imidazolidin-1-yl]-2-trifluoromethylbenzonitrile (959690-11-0)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate / tetrahydrofuran / 0 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 7 h / Inert atmosphere; Reflux

3: tetrahydrofuran; ethanol / 0.5 h / 20 °C / Inert atmosphere

4: tetrahydrofuran / 6 h / 20 °C / Inert atmosphere; Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrahydrofuran; tetrachloromethane; ethanol;

DOI:10.1021/jm300249m

upstream raw materials:

methyl 2-(4-hydroxyphenyl)-2-(2-propynyl)aminopropionate

4-isocyanato-2-(trifluoromethyl)benzonitrile

2-(4-Hydroxy-phenyl)-propionic acid

methyl 2-(4-acetoxyphenyl)-2-bromopropionate