{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Base Information

Chemical Name:{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid
CAS No.:1443043-37-5
Molecular Formula:C₂₅H₂₅ClFNO₄S
Molecular Weight:489.995
Hs Code.:

Synonyms:{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

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Chemical Property of {4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

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Technology Process of {4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

There total 12 articles about {4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1443043-38-6
{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

: 1443043-37-5
{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

Reference yield:

: 1227259-04-2
(4-benzyloxy-6-fluoro-3-methyl-naphthalen-2-yl)-acetic acid methyl ester

: 1443043-37-5
{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol

2.1: pyridine / dichloromethane / 3.17 h / 0 - 20 °C

3.1: zinc; lithium chloride; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 1.5 h / 20 - 68 °C / Inert atmosphere

3.2: 15 h / 65 °C / Inert atmosphere

4.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: sodium hydrogencarbonate / water / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

7.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C / Inert atmosphere

With pyridine; chloro-trimethyl-silane; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; zinc; In tetrahydrofuran; methanol; dichloromethane; water; ethylene dibromide;

Reference yield:

: 1227258-92-5
(6-fluoro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester

: 1443043-37-5
{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 3.17 h / 0 - 20 °C

2.1: zinc; lithium chloride; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 1.5 h / 20 - 68 °C / Inert atmosphere

2.2: 15 h / 65 °C / Inert atmosphere

3.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / water / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C / Inert atmosphere

With pyridine; chloro-trimethyl-silane; lithium hydroxide monohydrate; water; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; zinc; In tetrahydrofuran; dichloromethane; water; ethylene dibromide;