{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Base Information

Chemical Name:{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester
CAS No.:1443043-38-6
Molecular Formula:C₂₆H₂₇ClFNO₄S
Molecular Weight:504.022
Hs Code.:

Synonyms:{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Suppliers and Price of {4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of {4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of {4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

There total 11 articles about {4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1443042-94-1
(6-fluoro-3-methyl-4-piperidin-4-yl-naphthalen-2-yl)-acetic acid methyl ester

: 24974-73-0
(3-chlorophenyl)methanesulfonyl chloride

: 1443043-38-6
{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 1227259-04-2
(4-benzyloxy-6-fluoro-3-methyl-naphthalen-2-yl)-acetic acid methyl ester

: 1443043-38-6
{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: palladium 10% on activated carbon; hydrogen / methanol

2.1: pyridine / dichloromethane / 3.17 h / 0 - 20 °C

3.1: zinc; lithium chloride; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 1.5 h / 20 - 68 °C / Inert atmosphere

3.2: 15 h / 65 °C / Inert atmosphere

4.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: sodium hydrogencarbonate / water / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; chloro-trimethyl-silane; palladium 10% on activated carbon; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; zinc; In tetrahydrofuran; methanol; dichloromethane; water; ethylene dibromide;

Reference yield:

: 1227258-92-5
(6-fluoro-4-hydroxy-3-methyl-naphthalen-2-yl)-acetic acid methyl ester

: 1443043-38-6
{4-[1-(3-chloro-phenylmethanesulfonyl)-piperidin-4-yl]-6-fluoro-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine / dichloromethane / 3.17 h / 0 - 20 °C

2.1: zinc; lithium chloride; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 1.5 h / 20 - 68 °C / Inert atmosphere

2.2: 15 h / 65 °C / Inert atmosphere

3.1: dichloromethane / 2 h / 20 °C / Inert atmosphere

4.1: sodium hydrogencarbonate / water / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; chloro-trimethyl-silane; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; lithium chloride; zinc; In tetrahydrofuran; dichloromethane; water; ethylene dibromide;