2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N⁴-(2-phenylaminophenyl)cytidine

Base Information

Chemical Name:2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N⁴-(2-phenylaminophenyl)cytidine
CAS No.:242815-10-7
Molecular Formula:C₄₃H₄₂N₄O₆
Molecular Weight:710.83
Hs Code.:

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N<sup>4</sup>-(2-phenylaminophenyl)cytidine

Synonyms:2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N⁴-(2-phenylaminophenyl)cytidine

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Chemical Property of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N⁴-(2-phenylaminophenyl)cytidine

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Technology Process of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N⁴-(2-phenylaminophenyl)cytidine

There total 3 articles about 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N⁴-(2-phenylaminophenyl)cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 242815-07-2
3'-O-acetyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N⁴-(2-phenylaminophenyl)cytidine

: 242815-10-7
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N⁴-(2-phenylaminophenyl)cytidine

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 1h;
DOI:10.3891/acta.chem.scand.53-0497

Reference yield:

: 40615-37-0
3'-O-acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-deoxy-3,4-dihydrothymidine

: 242815-10-7
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N⁴-(2-phenylaminophenyl)cytidine

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 20 h / 20 °C

2: 67 percent / N,N-diisopropylethylamine / tetrahydrofuran / 36 h / Heating

3: 100 percent / NaOMe / methanol / 1 h / 20 °C

With dmap; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; 1: Acylation / 2: Substitution / 3: Deacetylation;
DOI:10.3891/acta.chem.scand.53-0497

Reference yield:

: 219556-92-0
1-[3-O-acetyl-2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-pentofuranosyl]-5-methyl-4-(2,4,6-trimethylbenzenesulfonyloxy)pyrimidin-2(1H)-one

: 242815-10-7
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-methyl-N⁴-(2-phenylaminophenyl)cytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / N,N-diisopropylethylamine / tetrahydrofuran / 36 h / Heating

2: 100 percent / NaOMe / methanol / 1 h / 20 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1: Substitution / 2: Deacetylation;
DOI:10.3891/acta.chem.scand.53-0497