1-phenyl-5-({6,6,6-trifluoro-5-[(triethylsilyl)oxy]hexyl}sulfonyl)-1H-tetrazole

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Chemical Name:1-phenyl-5-({6,6,6-trifluoro-5-[(triethylsilyl)oxy]hexyl}sulfonyl)-1H-tetrazole
CAS No.:1446488-70-5
Molecular Formula:C₁₉H₂₉F₃N₄O₃SSi
Molecular Weight:478.611
Hs Code.:

Synonyms:1-phenyl-5-({6,6,6-trifluoro-5-[(triethylsilyl)oxy]hexyl}sulfonyl)-1H-tetrazole

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Chemical Property of 1-phenyl-5-({6,6,6-trifluoro-5-[(triethylsilyl)oxy]hexyl}sulfonyl)-1H-tetrazole

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Technology Process of 1-phenyl-5-({6,6,6-trifluoro-5-[(triethylsilyl)oxy]hexyl}sulfonyl)-1H-tetrazole

There total 6 articles about 1-phenyl-5-({6,6,6-trifluoro-5-[(triethylsilyl)oxy]hexyl}sulfonyl)-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 994-30-9
triethylsilyl chloride

: 1446488-69-2
1,1,1-trifluoro-6-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]hexan-2-ol

: 1446488-70-5
1-phenyl-5-({6,6,6-trifluoro-5-[(triethylsilyl)oxy]hexyl}sulfonyl)-1H-tetrazole

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm400615g

Reference yield:

: 1446488-68-1
1,1,1-trifluoro-6-[(1-phenyl-1H-tetrazol-5-yl)thio]hexan-2-ol

: 1446488-70-5
1-phenyl-5-({6,6,6-trifluoro-5-[(triethylsilyl)oxy]hexyl}sulfonyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / ethanol / 16 h / 20 °C

2: 1H-imidazole; dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; In ethanol; dichloromethane;
DOI:10.1021/jm400615g

Reference yield:

: 111-29-5
1 ,5-pentanediol

: 1446488-70-5
1-phenyl-5-({6,6,6-trifluoro-5-[(triethylsilyl)oxy]hexyl}sulfonyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1: diethylazodicarboxylate; triphenylphosphine / tetrahydrofuran / 16 h / 0 - 20 °C

2: oxalyl dichloride / dichloromethane / 0.33 h / -78 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

4: dihydrogen peroxide; hexaammonium heptamolybdate tetrahydrate / ethanol / 16 h / 20 °C

5: 1H-imidazole; dmap / dichloromethane / 0.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; oxalyl dichloride; hexaammonium heptamolybdate tetrahydrate; tetrabutyl ammonium fluoride; dihydrogen peroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm400615g