methyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate

Base Information

Chemical Name:methyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate
CAS No.:1451372-06-7
Molecular Formula:C₃₀H₂₉NO₃
Molecular Weight:451.565
Hs Code.:

Synonyms:methyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate

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Chemical Property of methyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate

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Technology Process of methyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate

There total 11 articles about methyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₅H₃₇NO₅

: 1451372-06-7
methyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate

Guidance literature:: C₃₅H₃₇NO₅; With hydrogenchloride; In methanol; dichloromethane; at 20 ℃;

In hexane; isopropyl alcohol;

Reference yield:

: 1451373-94-6
tert-butyl ((R)-chroman-2-ylmethyl)((R)-1-(naphthalen-1-yl)ethyl)carbamate

: 1451372-06-7
methyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium sulfate; potassium permanganate / water; acetone / 16 h / 0 - 20 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

2.2: -78 - 20 °C / Inert atmosphere

3.1: sodium carbonate / water; toluene; ethanol / 0.33 h / Inert atmosphere

3.2: 1 h / 65 °C / Inert atmosphere

4.1: palladium 10% on activated carbon; hydrogen / methanol

5.1: hydrogenchloride / methanol; dichloromethane / 20 °C

5.2: CHIRAL IA; DEA

With hydrogenchloride; potassium permanganate; palladium 10% on activated carbon; hydrogen; potassium hexamethylsilazane; sodium carbonate; magnesium sulfate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetone; toluene;

Reference yield:

: 1451373-95-7
tert-butyl ((R)-1-(naphthalen-1-yl)ethyl)(((R)-4-oxochroman-2-yl)methyl)carbamate

: 1451372-06-7
methyl-3-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hexamethylsilazane / tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium carbonate / water; toluene; ethanol / 0.33 h / Inert atmosphere

2.2: 1 h / 65 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / methanol

4.1: hydrogenchloride / methanol; dichloromethane / 20 °C

4.2: CHIRAL IA; DEA

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; potassium hexamethylsilazane; sodium carbonate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;