Chromane-2-carboxylic acid

Base Information

Chemical Name:Chromane-2-carboxylic acid
CAS No.:51939-71-0
Molecular Formula:C10H10O3
Molecular Weight:178.188
Hs Code.:2932999099
European Community (EC) Number:818-423-1
DSSTox Substance ID:DTXSID20369080,DTXSID90901552
Nikkaji Number:J1.568.686C
Mol file:51939-71-0.mol

Synonyms:Chromane-2-carboxylic acid;51939-71-0;Chroman-2-carboxylic acid;3,4-dihydro-2H-chromene-2-carboxylic acid;3,4-dihydro-2H-1-benzopyran-2-carboxylic acid;MFCD00044719;Maybridge4_000177;2H-1-BENZOPYRAN-2-CARBOXYLIC ACID, 3,4-DIHYDRO-;2-carboxychroman;chroman carboxylic acid;NoName_683;2-chroman-carboxylic acid;2-Chromanecarboxylic Acid;SCHEMBL229558;AMY4358;DTXSID20369080;DTXSID90901552;SFLFCQJQOIZMHF-UHFFFAOYSA-N;HMS1521I01;(+/-)-Chroman-2-carboxylic acid;BCA93971;CCG-55377;AKOS005208243;AB01988;chromane-2-carboxylic acid, AldrichCPR;SB46037;SB46874;IDI1_030759;AS-35515;SY064639;3,4-dihydro-1-benzopyran-2-carboxylic acid;CS-0038563;FT-0623780;EN300-134546;3.4-dihydro-2H-1-benzopyran-2-carboxylic acid;A802726;A828857;SR-01000644403-1;(+)-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid;(-)-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid;F2108-0136;Z1198148530

Suppliers and Price of Chromane-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
chromane-2-carboxylic acid
500mg
$ 90.00

SynQuest Laboratories
Chroman-2-carboxylicacid 95.0%
5 g
$ 440.00

SynQuest Laboratories
Chroman-2-carboxylicacid 95.0%
1 g
$ 176.00

Sigma-Aldrich
chromane-2-carboxylic acid AldrichCPR
250 mg
$ 144.00

Matrix Scientific
Chromane-2-carboxylic acid 97%
1g
$ 341.00

Crysdot
chromane-2-carboxylic acid 95+%
25g
$ 720.00

Crysdot
chromane-2-carboxylic acid 95+%
100g
$ 1750.00

Crysdot
chromane-2-carboxylic acid 95+%
10g
$ 380.00

Crysdot
chromane-2-carboxylic acid 95+%
1g
$ 80.00

Crysdot
chromane-2-carboxylic acid 95+%
5g
$ 240.00

Total 30 raw suppliers

Chemical Property of Chromane-2-carboxylic acid

Chemical Property:

Vapor Pressure:1.09E-05mmHg at 25°C
Melting Point:99 °C
Refractive Index:1.575
Boiling Point:356.1 °C at 760 mmHg
PKA:3.09±0.20(Predicted)
Flash Point:146.9 °C
PSA：46.53000
Density:1.276g/cm³
LogP:1.46480
Storage Temp.:Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightly), Methanol (Slightly)
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:178.062994177
Heavy Atom Count:13
Complexity:202

Purity/Quality:

99%, ^*data from raw suppliers

chromane-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2=CC=CC=C2OC1C(=O)O
Uses Chromane-2-carboxylic Acid is used in the synthesis of 4-quinazolinones as Rho kinase inhibitors for application towards glaucoma, hypertension and spinal cord injuries. It is also used in the prepara tion of chromanyl-benzamidazoles as anti-bacterial compounds. Chromane-2-carboxylic Acid is used in the synthesis of 4-quinazolinones as Rho kinase inhibitors for application towards glaucoma, hypertension and spinal cord injuries. It is also used in the preparation of chromanyl-benzamidazoles as anti-bacterial compounds.

Technology Process of Chromane-2-carboxylic acid

There total 1 articles about Chromane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24698-77-9
ethyl Chroman-2-carboxylate

: 51939-71-0
chroman-2-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.orglett.8b01475

Reference yield: 93.0%

: 51939-71-0
chroman-2-carboxylic acid

: 64-17-5
ethanol

: 24698-77-9
ethyl Chroman-2-carboxylate

Guidance literature:: With sulfuric acid; In dichloromethane; for 21h; Heating;
DOI:10.1002/jhet.5570290223

Reference yield: 47.0%

: 51939-71-0
chroman-2-carboxylic acid

: 1446193-08-3
3-[(Z)-{[(2-amino-1,3-thiazol-4-yl)methoxy]imino}(phenyl)methyl]-2-methyl-1,2,4-oxadiazol-5(2H)-one

: 1446193-25-4
N-{4-[({[(Z)-(2-methyl-5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)(phenyl)methylene]amino}oxy)methyl]-1,3-thiazol-2-yl}chromane-2-carboxamide

Guidance literature:: chroman-2-carboxylic acid; With propylphosphonic anhydride; triethylamine; In dichloromethane; ethyl acetate; at 20 ℃; for 0.333333h;

3-[(Z)-{[(2-amino-1,3-thiazol-4-yl)methoxy]imino}(phenyl)methyl]-2-methyl-1,2,4-oxadiazol-5(2H)-one; In dichloromethane; ethyl acetate; for 5h; Reflux;