C₆H₃F₂O₂S^(1-)*Na⁽¹⁺⁾

Base Information

• Chemical Name: C₆H₃F₂O₂S^(1-)*Na⁽¹⁺⁾
• CAS No.: 1101821-02-6
• Molecular Formula: C₆H₃F₂O₂S*Na
• Molecular Weight: 200.141
• Mol file: 1101821-02-6.mol

Synonyms:C₆H₃F₂O₂S^(1-)*Na⁽¹⁺⁾

Chemical Property of C₆H₃F₂O₂S^(1-)*Na⁽¹⁺⁾

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆H₃F₂O₂S^(1-)*Na⁽¹⁺⁾

There total 4 articles about C₆H₃F₂O₂S^(1-)*Na⁽¹⁺⁾ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C10H10F2O4S → C6H3F2O2S(1-)*Na(1+) (1101821-02-6)

Guidance literature:

With sodium ethanolate; In methanol; at 50 ℃; for 4h;

DOI:10.1021/acs.orglett.9b03843

Reference yield:

2,5-difluorobenzenesulfonyl chloride (26120-86-5) → C6H3F2O2S(1-)*Na(1+) (1101821-02-6)

Guidance literature:

With sodium hydrogencarbonate; sodium sulfite; In tert-butyl methyl ether; water; at 20 - 25 ℃; for 2h;

Reference yield:

2-bromo-1,4-difluorobenzene (399-94-0) → C6H3F2O2S(1-)*Na(1+) (1101821-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 3 h / 100 °C

2: oxone||potassium monopersulfate triple salt / water; acetonitrile / 3 h / 25 °C

3: sodium ethanolate / methanol / 4 h / 50 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; oxone||potassium monopersulfate triple salt; sodium ethanolate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In methanol; water; toluene; acetonitrile;

DOI:10.1021/acs.orglett.9b03843

upstream raw materials:

2,5-difluorobenzenesulfonyl chloride

2-bromo-1,4-difluorobenzene

Downstream raw materials:

1,4-difluoro-2-methanesulfonyl-benzene

Refernces

• 1、 Liu, Wei,Deng, Wei,Sun, Saisai,Yu, Chunyan,Su, Xubo,Wu, Aliang,Yuan, Youlang,Ma, Zhonglin,Li, Ke,Yang, Hongfang,Peng, Xuanjia,Dietrich, Justin. "A Strategy for the Synthesis of Sulfonamides on DNA". . p. 9909 - 9913. Retrieved 2019/12/24.