4-[[3,3-difluoro-3-(4-fluorophenyl)-propyl]sulfanyl]thiazole-5-carboxylic acid

Base Information

Chemical Name:4-[[3,3-difluoro-3-(4-fluorophenyl)-propyl]sulfanyl]thiazole-5-carboxylic acid
CAS No.:1610889-97-8
Molecular Formula:C₁₃H₁₀F₃NO₂S₂
Molecular Weight:333.355
Hs Code.:

Synonyms:4-[[3,3-difluoro-3-(4-fluorophenyl)-propyl]sulfanyl]thiazole-5-carboxylic acid

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Chemical Property of 4-[[3,3-difluoro-3-(4-fluorophenyl)-propyl]sulfanyl]thiazole-5-carboxylic acid

Chemical Property:

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Technology Process of 4-[[3,3-difluoro-3-(4-fluorophenyl)-propyl]sulfanyl]thiazole-5-carboxylic acid

There total 7 articles about 4-[[3,3-difluoro-3-(4-fluorophenyl)-propyl]sulfanyl]thiazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1610889-96-7
4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester

: 1610889-97-8
4-[[3,3-difluoro-3-(4-fluorophenyl)-propyl]sulfanyl]thiazole-5-carboxylic acid

Guidance literature:: With water; potassium hydroxide; In ethanol; at 120 ℃; for 16h;

Reference yield:

: 1242643-02-2
acetic acid 2-[2-(4-fluorophenyl)-[1,3]dithiolan-2-yl]ethyl ester

: 1610889-97-8
4-[[3,3-difluoro-3-(4-fluorophenyl)-propyl]sulfanyl]thiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrofluoride / dichloromethane / 3.5 h / -78 - 20 °C

2: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

3: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

4: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

5: water; potassium hydroxide / ethanol / 16 h / 120 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; pyridine hydrofluoride; water; triethylamine; triphenylphosphine; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 66267-03-6
acetic acid [3-(4-fluorophenyl)-3-oxopropyl] ester

: 1610889-97-8
4-[[3,3-difluoro-3-(4-fluorophenyl)-propyl]sulfanyl]thiazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: boron trifluoride diethyl etherate / dichloromethane / 6 h / 0 - 20 °C

2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrofluoride / dichloromethane / 3.5 h / -78 - 20 °C

3: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

4: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

5: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

6: water; potassium hydroxide / ethanol / 16 h / 120 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; pyridine hydrofluoride; boron trifluoride diethyl etherate; water; triethylamine; triphenylphosphine; potassium hydroxide; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;