4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester

Base Information

Chemical Name:4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester
CAS No.:1610889-96-7
Molecular Formula:C₁₄H₁₂F₃NO₂S₂
Molecular Weight:347.382
Hs Code.:

Synonyms:4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester

Suppliers and Price of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester

There total 7 articles about 4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1242643-05-5
1-(3-bromo-1,1-difluoropropyl)-4-fluorobenzene

: 1610889-95-6
4-mercapto-thiazole-5-carboxylic acid methyl ester

: 1610889-96-7
4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1610889-94-5
4-(2-methoxycarbonylethylsulfanyl)thiazole-5-carboxylic acid methyl ester

: 1610889-96-7
4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; methanol / 1 h / 70 - 80 °C

2: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With methanol; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide;

Reference yield:

: 66267-03-6
acetic acid [3-(4-fluorophenyl)-3-oxopropyl] ester

: 1610889-96-7
4-[[3,3-difluoro-3-(4-fluorophenyl)propyl]sulfanyl]thiazole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: boron trifluoride diethyl etherate / dichloromethane / 6 h / 0 - 20 °C

2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; pyridine hydrofluoride / dichloromethane / 3.5 h / -78 - 20 °C

3: water; sodium hydroxide / ethanol / 1 h / 0 - 20 °C

4: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 - 20 °C

5: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; carbon tetrabromide; pyridine hydrofluoride; boron trifluoride diethyl etherate; water; triethylamine; triphenylphosphine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide;