4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester

Base Information

Chemical Name:4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester
CAS No.:349111-17-7
Molecular Formula:C₃₀H₃₃ClN₄O₇
Molecular Weight:597.068
Hs Code.:

4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester

Synonyms:4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester

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Chemical Property of 4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester

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Technology Process of 4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester

There total 8 articles about 4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 349111-16-6
4-[1-(tert-butoxycarbonyl-hydrazino)-ethyl]-benzoic acid methyl ester

: 179543-91-0,182887-52-1
7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)hydroquinoline-3-carboxylic acid

: 349111-17-7
4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester

Guidance literature:: 7-chloro-4-oxo-2-(pyrrolidinylcarbonyl)hydroquinoline-3-carboxylic acid; With CMC; In tetrahydrofuran; for 0.0833333h;

4-[1-(tert-butoxycarbonyl-hydrazino)-ethyl]-benzoic acid methyl ester; dmap; In tetrahydrofuran; Further stages.; Heating;
DOI:10.1021/jm060212s

Reference yield:

: 349111-15-5
C₁₅H₂₀N₂O₄

: 349111-17-7
4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 76 percent / H₂ / Pd/C / methanol / 24 h / 2068.65 Torr

2.1: CMC / tetrahydrofuran / 0.08 h

2.2: 71 percent / DMAP / tetrahydrofuran / Heating

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm060212s

Reference yield:

: 870-46-2
t-butoxycarbonylhydrazine

: 349111-17-7
4-(1-{N'-(tert-butoxycarbonylamino)-N-[7-chloro-4-hydroxy-2-(pyrrolidine-1-carbonyl)-quinoline-3-carboxyl]-hydrazino}-ethyl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / conc. HCl / tetrahydrofuran

2.1: 76 percent / H₂ / Pd/C / methanol / 24 h / 2068.65 Torr

3.1: CMC / tetrahydrofuran / 0.08 h

3.2: 71 percent / DMAP / tetrahydrofuran / Heating

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm060212s