1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine
CAS No.:1365803-08-2
Molecular Formula:C₁₃H₁₃F₃N₂O₂
Molecular Weight:286.254
Hs Code.:

Synonyms:1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Chemical Property:

Purity/Quality:

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Technology Process of 1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

There total 6 articles about 1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 1365803-07-1
4-(3-nitro-5-(trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine

: 1365803-08-2
1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Guidance literature:: With sodium tris(acetoxy)borohydride; In methanol; water; at 20 ℃; for 1h;

Reference yield:

: 630125-49-4
1-bromo-3-nitro-5-(trifluoromethyl)benzene

: 1365803-08-2
1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 80 °C

2: trifluoroacetic acid / dichloromethane / 20 °C

3: sodium tris(acetoxy)borohydride / water; methanol / 1 h / 20 °C

With sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1365803-08-2
1-methyl-4-[3-nitro-5-(trifluoromethyl)phenyl]-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 80 °C

2: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 80 °C

3: trifluoroacetic acid / dichloromethane / 20 °C

4: sodium tris(acetoxy)borohydride / water; methanol / 1 h / 20 °C

With potassium acetate; sodium tris(acetoxy)borohydride; potassium carbonate; trifluoroacetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;