1-methyl-1H-imidazole-2-carboxylic acid benzyl-(1-hydroxymethyl-2-methyl-propyl)-amide

Base Information

Chemical Name:1-methyl-1H-imidazole-2-carboxylic acid benzyl-(1-hydroxymethyl-2-methyl-propyl)-amide
CAS No.:1026873-83-5
Molecular Formula:C₁₇H₂₃N₃O₂
Molecular Weight:301.389
Hs Code.:

1-methyl-1<i>H</i>-imidazole-2-carboxylic acid benzyl-(1-hydroxymethyl-2-methyl-propyl)-amide

Synonyms:1-methyl-1H-imidazole-2-carboxylic acid benzyl-(1-hydroxymethyl-2-methyl-propyl)-amide

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Chemical Property of 1-methyl-1H-imidazole-2-carboxylic acid benzyl-(1-hydroxymethyl-2-methyl-propyl)-amide

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Technology Process of 1-methyl-1H-imidazole-2-carboxylic acid benzyl-(1-hydroxymethyl-2-methyl-propyl)-amide

There total 3 articles about 1-methyl-1H-imidazole-2-carboxylic acid benzyl-(1-hydroxymethyl-2-methyl-propyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 51081-36-8
2-lithium-N-methylimidazole

: 121328-33-4
3-benzyl-(4S)-isopropyl-1,3-oxazolidin-2-one

: 1026873-83-5
1-methyl-1H-imidazole-2-carboxylic acid benzyl-(1-hydroxymethyl-2-methyl-propyl)-amide

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1055/s-2003-44972

Reference yield:

: 100-39-0
benzyl bromide

: 1026873-83-5
1-methyl-1H-imidazole-2-carboxylic acid benzyl-(1-hydroxymethyl-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / 0 °C

2.1: 70 percent / tetrahydrofuran / 2 h / -78 °C

With n-butyllithium; In tetrahydrofuran;
DOI:10.1055/s-2003-44972

Reference yield:

: 17016-83-0
(4S)-4-isopropyl-1,3-oxazolidin-2-one

: 1026873-83-5
1-methyl-1H-imidazole-2-carboxylic acid benzyl-(1-hydroxymethyl-2-methyl-propyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / 0 °C

2.1: 70 percent / tetrahydrofuran / 2 h / -78 °C

With n-butyllithium; In tetrahydrofuran;
DOI:10.1055/s-2003-44972