(1S,5S)-6-benzyl-2-methoxy-8-methyl-6.8-diazabicyclo[3.2.2]nonane-2,7,9-trione

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Chemical Name:(1S,5S)-6-benzyl-2-methoxy-8-methyl-6.8-diazabicyclo[3.2.2]nonane-2,7,9-trione
CAS No.:269717-68-2
Molecular Formula:C₁₅H₁₆N₂O₃
Molecular Weight:272.304
Hs Code.:
Mol file:269717-68-2.mol

Synonyms:(1S,5S)-6-benzyl-2-methoxy-8-methyl-6.8-diazabicyclo[3.2.2]nonane-2,7,9-trione

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Chemical Property of (1S,5S)-6-benzyl-2-methoxy-8-methyl-6.8-diazabicyclo[3.2.2]nonane-2,7,9-trione Edit

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Technology Process of (1S,5S)-6-benzyl-2-methoxy-8-methyl-6.8-diazabicyclo[3.2.2]nonane-2,7,9-trione

There total 3 articles about (1S,5S)-6-benzyl-2-methoxy-8-methyl-6.8-diazabicyclo[3.2.2]nonane-2,7,9-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,5S)-6-benzyl-2-methoxy-8-methyl-2-(trimethylsiloxy)-6,8-diazabicyclo[3.2.2]nonane-7,9-dione

: 269717-68-2
(1S,5S)-6-benzyl-2-methoxy-8-methyl-6.8-diazabicyclo[3.2.2]nonane-2,7,9-trione

Guidance literature:: With toluene-4-sulfonic acid; In tetrahydrofuran; water; at 20 ℃; for 16h;
DOI:10.1016/S0968-0896(02)00043-3

Reference yield:

: 960599-34-2
dimethyl (+)-(R)-2-[N-benzyl-N-(2-chloroacetyl)amino]pentanedioate

: 269717-68-2
(1S,5S)-6-benzyl-2-methoxy-8-methyl-6.8-diazabicyclo[3.2.2]nonane-2,7,9-trione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 87 percent

2.1: LiHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: tetrahydrofuran / 3.5 h / -78 - 20 °C

3.1: 3.62 g / p-TsOH / tetrahydrofuran; H₂O / 12 h / 20 °C

With toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran; water; 1.1: Condensation / 2.1: Condensation / 2.2: Silylation / 3.1: Hydrolysis;
DOI:10.1021/ol990393a