(1R,3aS,6aR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

Base Information

Chemical Name:(1R,3aS,6aR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid
CAS No.:1393524-06-5
Molecular Formula:C₁₃H₂₁NO₄
Molecular Weight:255.314
Hs Code.:

Synonyms:(1R,3aS,6aR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

Suppliers and Price of (1R,3aS,6aR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,3aS,6aR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of (1R,3aS,6aR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

There total 7 articles about (1R,3aS,6aR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 926276-08-6,1549912-21-1
(3aR,6aS)-tert-butyl hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

: 124-38-9,18923-20-1
carbon dioxide

: 597569-42-1,926276-09-7
(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid

: 1393524-06-5,926276-09-7
(1R,3aS,6aR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

Guidance literature:: (3aR,6aS)-tert-butyl hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate; With sec.-butyllithium; (-)-sparteine; In hexane; tert-butyl methyl ether; at -75 - -70 ℃; for 3h; Industrial scale;

carbon dioxide; In hexane; tert-butyl methyl ether; at -75 - -70 ℃; for 1h; enantioselective reaction; Industrial scale;
DOI:10.1021/op500040j

Reference yield:

: 926276-08-6,1549912-21-1
(3aR,6aS)-tert-butyl hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

: 124-38-9,18923-20-1
carbon dioxide

: 597569-42-1,926276-09-7
(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid

: 1393524-06-5,926276-09-7
(1R,3aS,6aR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

: 926276-09-7
(1SR,3aSR,6aRS)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

Guidance literature:: (3aR,6aS)-tert-butyl hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate; With sec.-butyllithium; (1R,5S,11aS)-3-methyldecahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine; In hexane; tert-butyl methyl ether; at -75 - -70 ℃; for 3h; Industrial scale;

carbon dioxide; In hexane; tert-butyl methyl ether; at -75 - -70 ℃; for 1h; enantioselective reaction; Industrial scale;
DOI:10.1021/op500040j

Reference yield:

: 926276-09-7
(1SR,3aRS,6aSR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

: 597569-42-1,926276-09-7
(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid

: 1393524-06-5,926276-09-7
(1R,3aS,6aR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

Guidance literature:: (1SR,3aRS,6aSR)-2-(tert-butoxycarbonyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid; With (S)-1,2,3,4-tetrahydronapht-1-yl-amine; In ethyl acetate; for 2h; Resolution of racemate;

With sodium hydroxide;

With hydrogenchloride; In water;
DOI:10.1002/anie.200906655