(1R,3aR,5R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-one

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Chemical Name:(1R,3aR,5R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-one
CAS No.:869101-47-3
Molecular Formula:C₂₇H₄₆O
Molecular Weight:386.662
Hs Code.:

Synonyms:(1R,3aR,5R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-one

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Chemical Property of (1R,3aR,5R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-one

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Technology Process of (1R,3aR,5R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-one

There total 5 articles about (1R,3aR,5R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 66251-18-1
Grundmann's ketone

: 343974-48-1
(+/-)-1-(2-iodoethyl)-2-methylenecyclohexane

: 869101-47-3
(1R,3aR,5R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-one

Guidance literature:: Grundmann's ketone; With potassium hexamethylsilazane; In N,N-dimethyl-formamide; toluene;

(+/-)-1-(2-iodoethyl)-2-methylenecyclohexane; In N,N-dimethyl-formamide; toluene; at -78 ℃;
DOI:10.1021/jo050568w

Reference yield:

: 636-82-8
cyclohexene-1-carboxylic acid

: 869101-47-3
(1R,3aR,5R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 percent / lithium aluminum hydride / diethyl ether

2.1: Hg(OAc)2 / 160 °C

2.2: 82 percent / sodium borohydride / methanol

3.1: 67 percent / triphenylphosphine; imidazole; I₂

4.1: KHMDS / dimethylformamide; toluene

4.2: 68 percent / dimethylformamide; toluene / -78 °C

With 1H-imidazole; lithium aluminium tetrahydride; mercury(II) diacetate; iodine; potassium hexamethylsilazane; triphenylphosphine; In diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo050568w

Reference yield:

: 4845-04-9
1-cyclohexene-1-methanol

: 869101-47-3
(1R,3aR,5R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: Hg(OAc)2 / 160 °C

1.2: 82 percent / sodium borohydride / methanol

2.1: 67 percent / triphenylphosphine; imidazole; I₂

3.1: KHMDS / dimethylformamide; toluene

3.2: 68 percent / dimethylformamide; toluene / -78 °C

With 1H-imidazole; mercury(II) diacetate; iodine; potassium hexamethylsilazane; triphenylphosphine; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo050568w