(1R,3aR,4S,5R,7aR)-4-Allyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-ol

Base Information

Chemical Name:(1R,3aR,4S,5R,7aR)-4-Allyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-ol
CAS No.:343974-40-3
Molecular Formula:C₃₀H₅₂O
Molecular Weight:428.742
Hs Code.:

Synonyms:(1R,3aR,4S,5R,7aR)-4-Allyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-ol

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Chemical Property of (1R,3aR,4S,5R,7aR)-4-Allyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-ol

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Technology Process of (1R,3aR,4S,5R,7aR)-4-Allyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-ol

There total 7 articles about (1R,3aR,4S,5R,7aR)-4-Allyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 869101-47-3
(1R,3aR,5R,7aR)-1-((R)-1,5-Dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-one

: 1730-25-2
allylmagnesium bromide

: 343974-40-3
(1R,3aR,4S,5R,7aR)-4-Allyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-ol

Guidance literature:: In tetrahydrofuran; at -78 ℃;
DOI:10.1021/jo050568w

Reference yield:

: 636-82-8
cyclohexene-1-carboxylic acid

: 343974-40-3
(1R,3aR,4S,5R,7aR)-4-Allyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 percent / lithium aluminum hydride / diethyl ether

2.1: Hg(OAc)2 / 160 °C

2.2: 82 percent / sodium borohydride / methanol

3.1: 67 percent / triphenylphosphine; imidazole; I₂

4.1: KHMDS / dimethylformamide; toluene

4.2: 68 percent / dimethylformamide; toluene / -78 °C

5.1: 63 percent / tetrahydrofuran / -78 °C

With 1H-imidazole; lithium aluminium tetrahydride; mercury(II) diacetate; iodine; potassium hexamethylsilazane; triphenylphosphine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo050568w

Reference yield:

: 343974-48-1
(+/-)-1-(2-iodoethyl)-2-methylenecyclohexane

: 343974-40-3
(1R,3aR,4S,5R,7aR)-4-Allyl-1-((R)-1,5-dimethyl-hexyl)-7a-methyl-5-[2-(2-methylene-cyclohexyl)-ethyl]-octahydro-inden-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: KHMDS / dimethylformamide; toluene

1.2: 68 percent / dimethylformamide; toluene / -78 °C

2.1: 63 percent / tetrahydrofuran / -78 °C

With potassium hexamethylsilazane; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo050568w