Chemical Property of Cedrol
Chemical Property:
- Vapor Pressure:0.001mmHg at 25°C
- Melting Point:55-59 °C(lit.)
- Refractive Index:1.519
- Boiling Point:277.2 °C at 760 mmHg
- PKA:15.35±0.60(Predicted)
- Flash Point:115.5 °C
- PSA：20.23000
- Density:1 g/cm3
- LogP:3.60980
- Storage Temp.:2-8°C
- Solubility.:Soluble in DMSO (10 mg/ml)
- XLogP3:3.9
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:1
- Rotatable Bond Count:0
- Exact Mass:222.198365449
- Heavy Atom Count:16
- Complexity:321
- Purity/Quality:
-
99% *data from raw suppliers
(+)-Cedrol *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CC1CCC2C13CCC(C(C3)C2(C)C)(C)O
- Isomeric SMILES:C[C@@H]1CC[C@@H]2[C@]13CC[C@@]([C@H](C3)C2(C)C)(C)O
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Description
Cedrol is a sesquiterpene alcohol found in conifers mainly of the genera Cupressus, Juniperus, and Cedrus. It has been found to possess significant anticancer activity against glioblastoma in vitro and in vivo via cell growth inhibition, ROS generation, and DNA damage.1 Cedrol also displayed synergistic effects with temozolomide against glioblastoma in vitro and in vivo via reduced expression of drug resistance proteins.1,2 Cedrol inhibited the growth of human renal adenocarcinoma and amelanotic melanoma cells3 and induced autophagy and apoptosis in A549 non-small cell lung carcinoma cells4.
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Uses
acaricide, enhances skin ECM production (+)-Cedrol can be used as a starting material for the preparation of cedryl acetate by acetylation using acetic anhydride in the presence of an acid catalyst. It can also be incorporated as a precursor for the total synthesis of rare illicium sesquiterpene (+)-pseudoanisatin via selective C-H bond functionalization.
