N-(7-fluoro-2-formyl-1,3-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Base Information

Chemical Name:N-(7-fluoro-2-formyl-1,3-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide
CAS No.:1314129-39-9
Molecular Formula:C₂₃H₂₃FN₂O₄
Molecular Weight:410.445
Hs Code.:

Synonyms:N-(7-fluoro-2-formyl-1,3-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Chemical Property of N-(7-fluoro-2-formyl-1,3-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

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Technology Process of N-(7-fluoro-2-formyl-1,3-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

There total 9 articles about N-(7-fluoro-2-formyl-1,3-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1314129-37-7
ethyl 7-fluoro-1,3-dimethyl-6-([4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate

: 1314129-39-9
N-(7-fluoro-2-formyl-1,3-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: ethyl 7-fluoro-1,3-dimethyl-6-([4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 72h;

With manganese(IV) oxide; In tetrahydrofuran; at 80 ℃; for 2h;

Reference yield:

: 87392-07-2
(S)-tetrahydro-2-furoic acid

: 1314129-39-9
N-(7-fluoro-2-formyl-1,3-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 11 h / 22 - 75 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 10 °C

2.2: 2 - 4 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 96 h / 20 - 25 °C

3.2: 2 h / 90 °C

3.3: Cooling with ice

4.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 3 h / 50 °C

4.2: 72 h / 5 - 20 °C

5.1: hydrogen / palladium-on-charcoal / water; tetrahydrofuran / 15 h / 20 °C

5.2: 0.5 h / -25 - 5 °C

5.3: -20 °C

6.1: toluene-4-sulfonic acid / ethyl acetate; toluene / 2 h / 100 °C / Reflux

7.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 1 h / 5 °C

7.2: 15 h / 20 °C

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 20 °C

8.2: 2 h / 80 °C

With lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; hydrogen; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; palladium-on-charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; Pionier 2076; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1314129-39-9
N-(7-fluoro-2-formyl-1,3-dimethyl-1H-indol-6-yl)-4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 96 h / 20 - 25 °C

1.2: 2 h / 90 °C

1.3: Cooling with ice

2.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 3 h / 50 °C

2.2: 72 h / 5 - 20 °C

3.1: hydrogen / palladium-on-charcoal / water; tetrahydrofuran / 15 h / 20 °C

3.2: 0.5 h / -25 - 5 °C

3.3: -20 °C

4.1: toluene-4-sulfonic acid / ethyl acetate; toluene / 2 h / 100 °C / Reflux

5.1: sodium hydride / N,N-dimethyl-formamide; Pionier 2076 / 1 h / 5 °C

5.2: 15 h / 20 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / 20 °C

6.2: 2 h / 80 °C

With lithium aluminium tetrahydride; thionyl chloride; hydrogen; sodium hydride; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; palladium-on-charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; Pionier 2076; water; ethyl acetate; N,N-dimethyl-formamide; toluene;