ethyl 7-fluoro-3-methyl-6-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate

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Chemical Name:ethyl 7-fluoro-3-methyl-6-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate
CAS No.:1314129-17-3
Molecular Formula:C₂₄H₂₅FN₂O₅
Molecular Weight:440.471
Hs Code.:

Synonyms:ethyl 7-fluoro-3-methyl-6-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate

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Chemical Property of ethyl 7-fluoro-3-methyl-6-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate

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Technology Process of ethyl 7-fluoro-3-methyl-6-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate

There total 7 articles about ethyl 7-fluoro-3-methyl-6-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1314129-15-1
ethyl (2E)-2-{[2-fluoro-3-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)phenyl]hydrazono}butanoate

: 1314129-17-3
ethyl 7-fluoro-3-methyl-6-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In ethyl acetate; toluene; at 100 ℃; for 2h; Reflux;

Reference yield:

: 87392-07-2
(S)-tetrahydro-2-furoic acid

: 1314129-17-3
ethyl 7-fluoro-3-methyl-6-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 11 h / 22 - 75 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 10 °C

2.2: 2 - 4 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 96 h / 20 - 25 °C

3.2: 2 h / 90 °C

3.3: Cooling with ice

4.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 3 h / 50 °C

4.2: 72 h / 5 - 20 °C

5.1: hydrogen / palladium-on-charcoal / water; tetrahydrofuran / 15 h / 20 °C

5.2: 0.5 h / -25 - 5 °C

5.3: -20 °C

6.1: toluene-4-sulfonic acid / ethyl acetate; toluene / 2 h / 100 °C / Reflux

With lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; hydrogen; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; palladium-on-charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; water; ethyl acetate; toluene;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1314129-17-3
ethyl 7-fluoro-3-methyl-6-({4-[(2S)-tetrahydrofuran-2-ylmethoxy]benzoyl}amino)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 96 h / 20 - 25 °C

1.2: 2 h / 90 °C

1.3: Cooling with ice

2.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 3 h / 50 °C

2.2: 72 h / 5 - 20 °C

3.1: hydrogen / palladium-on-charcoal / water; tetrahydrofuran / 15 h / 20 °C

3.2: 0.5 h / -25 - 5 °C

3.3: -20 °C

4.1: toluene-4-sulfonic acid / ethyl acetate; toluene / 2 h / 100 °C / Reflux

With thionyl chloride; hydrogen; toluene-4-sulfonic acid; triphenylphosphine; diethylazodicarboxylate; palladium-on-charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; water; ethyl acetate; toluene;