2,4-di(benzyloxycarbonyl)butyl[hydroxy(phenyl)methyl]benzylphosphinic acid

Base Information

Chemical Name:2,4-di(benzyloxycarbonyl)butyl[hydroxy(phenyl)methyl]benzylphosphinic acid
CAS No.:200698-36-8
Molecular Formula:C₃₄H₃₅O₇P
Molecular Weight:586.621
Hs Code.:

Synonyms:2,4-di(benzyloxycarbonyl)butyl[hydroxy(phenyl)methyl]benzylphosphinic acid

Suppliers and Price of 2,4-di(benzyloxycarbonyl)butyl[hydroxy(phenyl)methyl]benzylphosphinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2,4-di(benzyloxycarbonyl)butyl[hydroxy(phenyl)methyl]benzylphosphinic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2,4-di(benzyloxycarbonyl)butyl[hydroxy(phenyl)methyl]benzylphosphinic acid

There total 3 articles about 2,4-di(benzyloxycarbonyl)butyl[hydroxy(phenyl)methyl]benzylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 100-52-7
benzaldehyde

: 200698-35-7
dibenzyl 2-[(benzyloxyphosphinyl)methyl]pentanedioate

: 200698-36-8
2,4-di(benzyloxycarbonyl)butyl[hydroxy(phenyl)methyl]benzylphosphinic acid

Guidance literature:: dibenzyl 2-[(benzyloxyphosphinyl)methyl]pentanedioate; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.25h;

benzaldehyde; In tetrahydrofuran; at 0 ℃; for 0.5h; Further stages.;
DOI:10.1021/jm0001774

Reference yield:

: 173039-05-9
dibenzyl 2-methylenepentanedioate

: 200698-36-8
2,4-di(benzyloxycarbonyl)butyl[hydroxy(phenyl)methyl]benzylphosphinic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 40 g / triethylammonium phosphinate; TMS-Cl; Et₃N / CHCl₃ / 6 h / 20 °C

2.1: 11.5 g / DMAP; dicyclohexylcarboxdiimide / CH₂Cl₂ / 0.5 h / 20 °C

3.1: NaH / tetrahydrofuran / 0.25 h / 0 °C

3.2: 33 percent / tetrahydrofuran / 0.5 h / 0 °C

With dmap; chloro-trimethyl-silane; triethylammonium phosphinate; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jm0001774

Reference yield:

: 200698-34-6
2,4-di(benzyloxycarbonyl)butylphosphinic acid

: 200698-36-8
2,4-di(benzyloxycarbonyl)butyl[hydroxy(phenyl)methyl]benzylphosphinic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 11.5 g / DMAP; dicyclohexylcarboxdiimide / CH₂Cl₂ / 0.5 h / 20 °C

2.1: NaH / tetrahydrofuran / 0.25 h / 0 °C

2.2: 33 percent / tetrahydrofuran / 0.5 h / 0 °C

With dmap; sodium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm0001774