(2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Base Information

• Chemical Name: (2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine
• CAS No.: 1220352-28-2
• Molecular Formula: C₂₀H₂₀F₃NO₃
• Molecular Weight: 379.379

Synonyms:(2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Chemical Property of (2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

Chemical Property:

Purity/Quality:

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SDS file from LookChem

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Technology Process of (2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

There total 1 articles about (2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2S,4R)-2-trifluoromethyl-3-[(R)-2-hydroxypropanoyl]-4-phenyl-1,3-oxazolidine (1220352-21-5) + benzyl bromide (100-39-0) → (2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine (1220352-28-2)

Guidance literature:

(2S,4R)-2-trifluoromethyl-3-[(R)-2-hydroxypropanoyl]-4-phenyl-1,3-oxazolidine; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.75h; Inert atmosphere;

benzyl bromide; In tetrahydrofuran; at 0 - 20 ℃; optical yield given as %de; Inert atmosphere;

DOI:10.1021/ol100211s

Reference yield: 82.0%

(2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine (1220352-28-2) → (R)-2-benzyloxypropionic acid (100836-85-9) + (2S,4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine (203176-56-1)

Guidance literature:

(2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine; With lithium aluminium tetrahydride; In diethyl ether; at -10 ℃; for 2h; Inert atmosphere;

With water; sodium hydroxide; In diethyl ether; Further stages; Inert atmosphere;

DOI:10.1021/ol100211s

Reference yield: 51.0%

(2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine (1220352-28-2) → (R)-2-(benzyloxy)propan-1-ol (87037-69-2) + (2S,4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine (203176-56-1)

Guidance literature:

(2S,4R)-3-[(R)-2-benzyloxypropanoyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine; With lithium aluminium tetrahydride; In diethyl ether; at -10 ℃; for 2h; Inert atmosphere;

With water; sodium hydroxide; In diethyl ether; Further stages; Inert atmosphere;

DOI:10.1021/ol100211s

upstream raw materials:

(2S,4R)-2-trifluoromethyl-3-[(R)-2-hydroxypropanoyl]-4-phenyl-1,3-oxazolidine

benzyl bromide

Downstream raw materials:

(2S,4R)-3-[(R)-2-benzyloxy-1-hydroxypropyl]-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

(R)-2-benzyloxypropanal

(2S,4R)-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

(R)-2-benzyloxypropionic acid

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