(R)-2-(4-aminobenzenesulfonylamino)-3-(1H-indol-3-yl)propionic acid methyl ester

Base Information

Chemical Name:(R)-2-(4-aminobenzenesulfonylamino)-3-(1H-indol-3-yl)propionic acid methyl ester
CAS No.:203639-63-8
Molecular Formula:C₁₈H₁₉N₃O₄S
Molecular Weight:373.433
Hs Code.:

Synonyms:(R)-2-(4-aminobenzenesulfonylamino)-3-(1H-indol-3-yl)propionic acid methyl ester

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Chemical Property of (R)-2-(4-aminobenzenesulfonylamino)-3-(1H-indol-3-yl)propionic acid methyl ester

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Technology Process of (R)-2-(4-aminobenzenesulfonylamino)-3-(1H-indol-3-yl)propionic acid methyl ester

There total 3 articles about (R)-2-(4-aminobenzenesulfonylamino)-3-(1H-indol-3-yl)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 203639-62-7
(R)-3-(1H-indol-3-yl)-2-(4-nitrobenzenesulfonylamino)propionic acid methyl ester

: 203639-63-8
(R)-2-(4-aminobenzenesulfonylamino)-3-(1H-indol-3-yl)propionic acid methyl ester

Guidance literature:: With palladium 10% on activated carbon; In methanol; water; ethyl acetate; at 20 ℃; for 6.66667h;
DOI:10.1021/jm400156p

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 203639-63-8
(R)-2-(4-aminobenzenesulfonylamino)-3-(1H-indol-3-yl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine / CH₂Cl₂ / 2 h / Ambient temperature

2: H₂ / 10percent Pd/C / methanol; ethyl acetate

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm9707582

Reference yield:

: 14907-27-8,5619-09-0,7524-52-9,26988-71-6,41222-70-2,67557-19-1,109492-62-8
(R)-(+)-tryptophan methyl ester hydrochloride

: 203639-63-8
(R)-2-(4-aminobenzenesulfonylamino)-3-(1H-indol-3-yl)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine / dichloromethane / 2 h / 0 - 20 °C

2: palladium 10% on activated carbon / methanol; ethyl acetate; water / 6.67 h / 20 °C

With 4-methyl-morpholine; palladium 10% on activated carbon; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm400156p