1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate
CAS No.:1095274-57-9
Molecular Formula:C₂₂H₂₆ClN₃O₅
Molecular Weight:447.919
Hs Code.:

Synonyms:1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

There total 8 articles about 1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095274-52-4
ethyl [5-(3-bromo-5-chlorophenyl)-1,3,4-oxadiazol-2-yl]acetate

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1095274-57-9
1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; water; at 100 ℃; for 0.333333h; Microwave irradion;

Reference yield:

: 42860-02-6
3‐bromo‐5‐chlorobenzoic acid

: 1095274-57-9
1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h / 20 °C

2: Burgess Reagent / dichloromethane / 0.33 h / 100 °C / Microwave irradition

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 100 °C / Microwave irradion

With 4-methyl-morpholine; Burgess Reagent; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1095274-56-8
3-bromo-5-chlorobenzohydrazide

: 1095274-57-9
1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.33 h / 20 °C

2: Burgess Reagent / dichloromethane / 0.33 h / 100 °C / Microwave irradition

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 100 °C / Microwave irradion

With Burgess Reagent; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;