{5-[3-chloro-5-(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1,2,3,6-tetrahydro-4-pyridinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid lithium salt

Base Information

Chemical Name:{5-[3-chloro-5-(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1,2,3,6-tetrahydro-4-pyridinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid lithium salt
CAS No.:1095274-58-0
Molecular Formula:C₂₀H₂₁ClN₃O₅*Li
Molecular Weight:425.798
Hs Code.:

Synonyms:{5-[3-chloro-5-(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1,2,3,6-tetrahydro-4-pyridinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid lithium salt

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Chemical Property of {5-[3-chloro-5-(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1,2,3,6-tetrahydro-4-pyridinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid lithium salt

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Technology Process of {5-[3-chloro-5-(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1,2,3,6-tetrahydro-4-pyridinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid lithium salt

There total 8 articles about {5-[3-chloro-5-(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1,2,3,6-tetrahydro-4-pyridinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid lithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095274-57-9
1,1-dimethylethyl 4-(3-chloro-5-{5-[2-(ethyloxy)-2-oxoethyl]-1,3,4-oxadiazol-2-yl}phenyl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1095274-58-0
{5-[3-chloro-5-(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1,2,3,6-tetrahydro-4-pyridinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid lithium salt

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1095274-55-7
3-bromo-5-chlorobenzoic acid ethyl ester

: 1095274-58-0
{5-[3-chloro-5-(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1,2,3,6-tetrahydro-4-pyridinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid lithium salt

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine / ethanol / 80 °C

2: tetrahydrofuran / 0.33 h / 20 °C

3: Burgess Reagent / dichloromethane / 0.33 h / 100 °C / Microwave irradition

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 100 °C / Microwave irradion

5: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With lithium hydroxide; Burgess Reagent; water; sodium carbonate; hydrazine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water;

Reference yield:

: 1095274-56-8
3-bromo-5-chlorobenzohydrazide

: 1095274-58-0
{5-[3-chloro-5-(1-{[(1,1-dimethylethyl)oxy]carbonyl}-1,2,3,6-tetrahydro-4-pyridinyl)phenyl]-1,3,4-oxadiazol-2-yl}acetic acid lithium salt

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0.33 h / 20 °C

2: Burgess Reagent / dichloromethane / 0.33 h / 100 °C / Microwave irradition

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 0.33 h / 100 °C / Microwave irradion

4: lithium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

With lithium hydroxide; Burgess Reagent; water; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;