1-Chloro-6,6-dimethyl-5-hept-2-en-4-ino

Base Information

• Chemical Name: 1-Chloro-6,6-dimethyl-5-hept-2-en-4-ino
• CAS No.: 126764-17-8
• Molecular Formula: C9H13Cl
• Molecular Weight: 156.655
• Hs Code.: 29032990
• Mol file: 126764-17-8.mol

Synonyms:1-Chloro-6,6-dimethyl-2-hepten-4-yne;Terbinafine intermediate;1-chloro-6,6-dimethyl-2-heptyene-4-alkyne;1-chloro-6,6-dimethyl-2-hepten-4-yn;1-chloro-6,6-dimethyl-2-ene-4-yene-heptane;trans-1-chloro-6,6-dimethyl-2-heptene-4-yne;2-hepten-4-yne, 1-chloro-6,6-dimethyl-, (2e)-;

Chemical Property of 1-Chloro-6,6-dimethyl-5-hept-2-en-4-ino

Chemical Property:

• Vapor Pressure: 0.324mmHg at 25°C
• Refractive Index: 1.475
• Boiling Point: 207.5 °C at 760 mmHg
• Flash Point: 74.7 °C
• PSA: 0.00000
• Density: 0.946 g/cm³
• LogP: 2.83090
• Storage Temp.: Amber Vial, Refrigerator, Under Inert Atmosphere
• Solubility.: Chloroform, Ethyl Acetate (Slightly), Hexane (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

1-Chloro-6,6-dimethyl-2-hepten-4-yne ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An intermediate in the synthesis of Terbinafine (T107500).

Technology Process of 1-Chloro-6,6-dimethyl-5-hept-2-en-4-ino

There total 1 articles about 1-Chloro-6,6-dimethyl-5-hept-2-en-4-ino which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-6,6-dimethylhept-1-ene-4-yne (78629-20-6) → 1-chloro-6,6-dimethyl-2-hepten-4-yne (126764-17-8)

Guidance literature:

With hydrogenchloride; trichlorophosphate; In water; acetonitrile; at 10 - 28 ℃; for 6.33333h;

Reference yield:

1-chloro-6,6-dimethyl-2-hepten-4-yne (126764-17-8) + N-methyl-1-naphthalenemethylamine (14489-75-9) → terbinafine hydrochloride (78628-80-5,176168-78-8)

Guidance literature:

1-chloro-6,6-dimethyl-2-hepten-4-yne; N-methyl-1-naphthalenemethylamine; With sodium hydroxide; In water; at 20 - 100 ℃; for 2h;

With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 1h;

Reference yield:

1-chloro-6,6-dimethyl-2-hepten-4-yne (126764-17-8) + N-methyl-1-naphthalenemethylamine hydrochloride (65473-13-4) → terbinafine hydrochloride (78628-80-5,176168-78-8)

Guidance literature:

1-chloro-6,6-dimethyl-2-hepten-4-yne; N-methyl-1-naphthalenemethylamine hydrochloride; With sodium carbonate; In water; N,N-dimethyl-formamide; at 11 - 60 ℃; for 6.25h;

With hydrogenchloride; In water; for 0.5h; pH=0.2;

upstream raw materials:

3-hydroxy-6,6-dimethylhept-1-ene-4-yne

Downstream raw materials:

terbinafine hydrochloride

terbinafin

Refernces

• 1、 -. "IMPROVED PROCESS FOR THE PREPARATION OF TERBINAFINE HYDROCHLORIDE AND NOVEL CRYSTALLINE FORM OF TERBINAFINE". Page/Page column 20. . Retrieved 2010/11/28.