6-chloro-7,8-dimethoxy-3-methyl-9-(phenylthio)-2,3,4,5-tetrahydro-1H-3-benzazepine

Base Information

Chemical Name:6-chloro-7,8-dimethoxy-3-methyl-9-(phenylthio)-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS No.:82614-92-4
Molecular Formula:C₁₉H₂₂ClNO₂S
Molecular Weight:363.908
Hs Code.:

Synonyms:6-chloro-7,8-dimethoxy-3-methyl-9-(phenylthio)-2,3,4,5-tetrahydro-1H-3-benzazepine

Suppliers and Price of 6-chloro-7,8-dimethoxy-3-methyl-9-(phenylthio)-2,3,4,5-tetrahydro-1H-3-benzazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-chloro-7,8-dimethoxy-3-methyl-9-(phenylthio)-2,3,4,5-tetrahydro-1H-3-benzazepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-chloro-7,8-dimethoxy-3-methyl-9-(phenylthio)-2,3,4,5-tetrahydro-1H-3-benzazepine

There total 9 articles about 6-chloro-7,8-dimethoxy-3-methyl-9-(phenylthio)-2,3,4,5-tetrahydro-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 73943-28-9
2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylsulfinyl)-1H-3-benzazepine

: 73942-96-8
2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylthio)-1H-3-benzazepine

: 82614-92-4
6-chloro-7,8-dimethoxy-3-methyl-9-(phenylthio)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With thionyl chloride; In dichloromethane; 1.) a) -78 deg C, 1 h, b) from 0 to 10 deg C, 4 h, c) from 10 deg C to RT, 1 d;
DOI:10.1021/jo00141a011

Reference yield:

: 37462-47-8
7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepine

: 82614-92-4
6-chloro-7,8-dimethoxy-3-methyl-9-(phenylthio)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / Et₃N / toluene / Heating

2: 43 percent / ZnCl₂ / CCl₄ / 1.) a) from -15 deg C to RT, overnight, b) RT, 24 h

3: 47 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

4: 76 percent / NaIO₄ / methanol / 1.) a) RT, 1 h, b) 40 deg C, overnight

5: 55 percent / SOCl₂ / CH₂Cl₂ / 1.) a) -78 deg C, 1 h, b) from 0 to 10 deg C, 4 h, c) from 10 deg C to RT, 1 d

With sodium periodate; lithium aluminium tetrahydride; thionyl chloride; triethylamine; zinc(II) chloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/jo00141a011

Reference yield:

: 73942-96-8
2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylthio)-1H-3-benzazepine

: 82614-92-4
6-chloro-7,8-dimethoxy-3-methyl-9-(phenylthio)-2,3,4,5-tetrahydro-1H-3-benzazepine

Guidance literature:: With sulfuryl dichloride; In dichloromethane; 1.) a) -78 deg C, 1 h, b) from 0 to 10 deg C, 4 h, c) from 10 deg C to RT, 1 d;
DOI:10.1021/jo00141a011