2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylsulfinyl)-1H-3-benzazepine

Base Information

Chemical Name:2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylsulfinyl)-1H-3-benzazepine
CAS No.:73943-28-9
Molecular Formula:C₁₉H₂₃NO₃S
Molecular Weight:345.463
Hs Code.:

Synonyms:2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylsulfinyl)-1H-3-benzazepine

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Chemical Property of 2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylsulfinyl)-1H-3-benzazepine

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Technology Process of 2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylsulfinyl)-1H-3-benzazepine

There total 6 articles about 2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylsulfinyl)-1H-3-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 73942-96-8
2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylthio)-1H-3-benzazepine

: 73943-28-9
2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylsulfinyl)-1H-3-benzazepine

Guidance literature:: With sodium periodate; In methanol; 1.) a) RT, 1 h, b) 40 deg C, overnight;
DOI:10.1021/jo00141a011

Reference yield:

: 37462-47-8
7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepine

: 73943-28-9
2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylsulfinyl)-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / Et₃N / toluene / Heating

2: 43 percent / ZnCl₂ / CCl₄ / 1.) a) from -15 deg C to RT, overnight, b) RT, 24 h

3: 47 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

4: 76 percent / NaIO₄ / methanol / 1.) a) RT, 1 h, b) 40 deg C, overnight

With sodium periodate; lithium aluminium tetrahydride; triethylamine; zinc(II) chloride; In tetrahydrofuran; methanol; tetrachloromethane; toluene;
DOI:10.1021/jo00141a011

Reference yield:

: 73943-23-4
6-bromo-2,3,4,5-tetrahydro-7,8-dimethoxy-1H-3-benzazepine

: 73943-28-9
2,3,4,5-tetrahydro-7,8-dimethoxy-3-methyl-6-(phenylsulfinyl)-1H-3-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) toluene, hexane, ether, -78 deg C, 45 min, 2.) a) -78 deg C, 5 h, b) from -78 deg C to RT, overnight

2: 76 percent / NaIO₄ / methanol / 1.) a) RT, 1 h, b) 40 deg C, overnight

With sodium periodate; n-butyllithium; In methanol;
DOI:10.1021/jo00141a011