BOC-D-2-Chlorophe

Base Information

• Chemical Name: BOC-D-2-Chlorophe
• CAS No.: 80102-23-4
• Molecular Formula: C₁₄H₁₈ClNO₄
• Molecular Weight: 299.754
• Hs Code.: 2924299090
• Mol file: 80102-23-4.mol

Synonyms:Boc-D-Phe(2-Cl)-OH;Boc-D-2-Chlorophe;tert-Butoxycarbonyl-D-2-chlorophenylalanine;

Chemical Property of BOC-D-2-Chlorophe

Chemical Property:

• Melting Point: 94-98 °C
• Boiling Point: 452.5 °C at 760 mmHg
• PKA: 3.83±0.11(Predicted)
• Flash Point: 227.5 °C
• PSA: 75.63000
• Density: 1.245 g/cm³
• LogP: 3.25130
• Storage Temp.: Store at 0°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Boc-2-Chloro-D-phenylalanine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-D-2-Chlorophe

There total 2 articles about BOC-D-2-Chlorophe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H20ClNO4 (1254365-74-6) → (R)-2-((tert-butoxycarbonyl)amino)-3-(2-chlorophenyl)propanoic acid (114873-02-8,80102-23-4,1407973-04-9)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 0 ℃; for 6h;

DOI:10.1016/j.bmcl.2010.08.053

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (2S)-2-amino-3-(2-chlorophenyl)propanoic acid (103616-89-3,80126-50-7) → Nα-[(tert-butoxy)carbonyl]-2-(chloro)-L-phenylalanine (114873-02-8,80102-23-4,1407973-04-9)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 22 ℃;

DOI:10.1021/acs.jmedchem.7b01870

Reference yield:

(R)-2-((tert-butoxycarbonyl)amino)-3-(2-chlorophenyl)propanoic acid (114873-02-8,80102-23-4,1407973-04-9) + methyl iodide (74-88-4) → C15H20ClNO4 (1254365-74-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1016/j.tet.2014.04.045

upstream raw materials:

C₁₅H₂₀ClNO₄

di-tert-butyl dicarbonate

(2S)-2-amino-3-(2-chlorophenyl)propanoic acid

Downstream raw materials:

(R)-2-chlorophenylalanine methyl ester hydrochloride

(R)-N-(2-chloroacetyl)-2-chlorophenylalanine methyl ester

(R)-N-[N-(2,2-dimethoxyethyl)glycinyl]-2-chlorophenylalanine methyl ester

C₁₅H₂₀ClNO₄

Refernces

• 1、 Blake, James F.,Kallan, Nicholas C.,Xiao, Dengming,Xu, Rui,Bencsik, Josef R.,Skelton, Nicholas J.,Spencer, Keith L.,Mitchell, Ian S.,Woessner, Richard D.,Gloor, Susan L.,Risom, Tyler,Gross, Stefan D.,Martinson, Matthew,Morales, Tony H.,Vigers, Guy P.A.,Brandhuber, Barbara J.. "Discovery of pyrrolopyrimidine inhibitors of Akt". scheme or table. p. 5607 - 5612. Retrieved 2010/11/17.