methanesulfonic acid 3-{4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]phenyl}-propylester

Base Information

• Chemical Name: methanesulfonic acid 3-{4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]phenyl}-propylester
• CAS No.: 205318-87-2
• Molecular Formula: C₂₁H₂₃NO₆S
• Molecular Weight: 417.483

Synonyms:methanesulfonic acid 3-{4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]phenyl}-propylester

Chemical Property of methanesulfonic acid 3-{4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]phenyl}-propylester

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Technology Process of methanesulfonic acid 3-{4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]phenyl}-propylester

There total 3 articles about methanesulfonic acid 3-{4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]phenyl}-propylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanesulfonyl chloride (124-63-0) + 2-{3-[4-(3-hydroxy-propyl)-phenoxy]-propyl}-isoindole-1,3-dione (205318-86-1) → methanesulfonic acid 3-{4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]phenyl}-propylester (205318-87-2)

Guidance literature:

With pyridine; at 0 ℃; for 16h;

DOI:10.1016/S0960-894X(98)00003-1

Reference yield:

2-(3-bromopropyl)isoindole-1,3-dione (5460-29-7) → methanesulfonic acid 3-{4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]phenyl}-propylester (205318-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / K₂CO₃ / acetone / 24 h / Heating

2: 99 percent / pyridine / 16 h / 0 °C

With pyridine; potassium carbonate; In acetone;

DOI:10.1016/S0960-894X(98)00003-1

Reference yield:

3-(4-hydroxyphenyl)propan-1-ol (10210-17-0) → methanesulfonic acid 3-{4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]phenyl}-propylester (205318-87-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / K₂CO₃ / acetone / 24 h / Heating

2: 99 percent / pyridine / 16 h / 0 °C

With pyridine; potassium carbonate; In acetone;

DOI:10.1016/S0960-894X(98)00003-1

upstream raw materials:

methanesulfonyl chloride

2-{3-[4-(3-hydroxy-propyl)-phenoxy]-propyl}-isoindole-1,3-dione

2-(3-bromopropyl)isoindole-1,3-dione

3-(4-hydroxyphenyl)propan-1-ol

Downstream raw materials:

2-{3-[4-(3-Piperazin-1-yl-propyl)-phenoxy]-propyl}-isoindole-1,3-dione

2-[3-(4-{3-[4-(2-Benzhydryloxy-ethyl)-piperazin-1-yl]-propyl}-phenoxy)-propyl]-isoindole-1,3-dione

3-(4-{3-[4-(2-benzhydryloxy-ethyl)-piperazine-1-yl]-propyl}-phenoxy)-propylamine

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