1-<2-deoxy-3-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane

Base Information

Chemical Name:1-<2-deoxy-3-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane
CAS No.:173776-20-0
Molecular Formula:C₃₃H₃₆N₂O₇
Molecular Weight:572.658
Hs Code.:

Synonyms:1-<2-deoxy-3-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane

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Chemical Property of 1-<2-deoxy-3-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane

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Technology Process of 1-<2-deoxy-3-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane

There total 12 articles about 1-<2-deoxy-3-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 173776-19-7
1-{2-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-ethyl}-5-methyl-1H-pyrimidine-2,4-dione

: 173776-20-0
1-<2-deoxy-3-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 2h; Yield given;
DOI:10.1016/0040-4039(95)01932-8

Reference yield:

: 173776-11-9
1-(2-deoxy-α-D-erythro-pentofuranosyl)-2-(thymin-1-yl)ethane

: 173776-20-0
1-<2-deoxy-3-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 1 h / 25 °C

2: DMAP / benzene / 25 °C

3: 1 M n-Bu₄NF / tetrahydrofuran / 2 h / 25 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo961548k

Reference yield:

: 173776-18-6
1-<2-deoxy-5-O-(tert-butyldimethylsilyl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane

: 173776-20-0
1-<2-deoxy-3-O-(4,4'-dimethoxytrityl)-α-D-erythro-pentofuranosyl>-2-(thymin-1-yl)ethane

Guidance literature:: Multi-step reaction with 2 steps

1: DMAP / benzene / 25 °C

2: 1 M n-Bu₄NF / tetrahydrofuran / 2 h / 25 °C

With dmap; tetrabutyl ammonium fluoride; In tetrahydrofuran; benzene;
DOI:10.1021/jo961548k