C₂₁H₂₈O₆

Base Information

Chemical Name:C₂₁H₂₈O₆
CAS No.:1449483-67-3
Molecular Formula:C₂₁H₂₈O₆
Molecular Weight:376.45
Hs Code.:

C<sub>21</sub>H<sub>28</sub>O<sub>6</sub>

Synonyms:C₂₁H₂₈O₆

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Chemical Property of C₂₁H₂₈O₆

Chemical Property:

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Technology Process of C₂₁H₂₈O₆

There total 34 articles about C₂₁H₂₈O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1392307-60-6
ethyl 3-((1R,2S,3R,4R,5R)-3-(benzyloxy)-1,4-dihydroxy-5-methyl-2-vinylcyclohexyl)propiolate

: 1392307-62-8
(Z)-ethyl 2-((1R,4R,5S,6R,7R)-6-(benzyloxy)-4-hydroxy-7-methyl-5-vinyl-2-oxabicyclo[2.2.2]octan-3-ylidene)acetate

: 1449483-67-3
C₂₁H₂₈O₆

Guidance literature:: With (triphenylphosphine)gold(I)bis(trifluoromethanesulfonyl)imidate; In isopropyl alcohol; at 70 ℃; for 1.5h; Overall yield = 85 %;
DOI:10.1039/c3ob40692j

Reference yield:

: (S)-4-benzyl-3-((2S,3R,4R)-2-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-4,8-dimethylnon-7-enoyl)oxazolidin-2-one

: 1449483-67-3
C₂₁H₂₈O₆

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium tetrahydroborate / water; tetrahydrofuran / 20 h / 0 - 20 °C

2.1: Dess-Martin periodane / dichloromethane / 2.5 h / 20 °C

2.2: 20 h / 20 °C

3.1: diisobutylaluminium hydride / toluene; diethyl ether / 0.25 h / -40 °C / Inert atmosphere

4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 15 h / 0 °C / Inert atmosphere

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Cooling with ice

6.1: periodic acid dihydrate / diethyl ether / 0.25 h

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyrrolidine / tetrahydrofuran / 20 °C / Inert atmosphere

8.1: triethylamine / dichloromethane / 1 h / 50 °C / Inert atmosphere

9.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.25 h / 20 °C

9.2: 2 h / 20 °C

10.1: diisopropylamine; n-butyllithium / hexane; toluene / 0.5 h / -78 °C

10.2: 0.33 h / -78 - 0 °C

10.3: 9 h / 60 °C

11.1: (triphenylphosphine)gold(I)bis(trifluoromethanesulfonyl)imidate / isopropyl alcohol / 1.5 h / 70 °C

With pyrrolidine; sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; periodic acid dihydrate; carbon tetrabromide; (triphenylphosphine)gold(I)bis(trifluoromethanesulfonyl)imidate; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; isopropyl alcohol; toluene;
DOI:10.1039/c3ob40692j

Reference yield:

: 1392307-50-4
(2R,3R,4R)-2-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-4,8-dimethylnon-7-en-1-ol

: 1449483-67-3
C₂₁H₂₈O₆

Guidance literature:: Multi-step reaction with 10 steps

1.1: Dess-Martin periodane / dichloromethane / 2.5 h / 20 °C

1.2: 20 h / 20 °C

2.1: diisobutylaluminium hydride / toluene; diethyl ether / 0.25 h / -40 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 20 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / -10 °C

5.1: periodic acid dihydrate / diethyl ether / 0.25 h

6.1: triphenylphosphine; pyrrolidine; palladium diacetate / dimethyl sulfoxide / 20 °C

7.1: triethylamine / dichloromethane / 1 h / 50 °C / Inert atmosphere

8.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.25 h / 20 °C

8.2: 2 h / 20 °C

9.1: diisopropylamine; n-butyllithium / hexane; toluene / 0.5 h / -78 °C

9.2: 0.33 h / -78 - 0 °C

9.3: 9 h / 60 °C

10.1: (triphenylphosphine)gold(I)bis(trifluoromethanesulfonyl)imidate / isopropyl alcohol / 1.5 h / 70 °C

With pyrrolidine; dmap; n-butyllithium; periodic acid dihydrate; (triphenylphosphine)gold(I)bis(trifluoromethanesulfonyl)imidate; palladium diacetate; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In diethyl ether; hexane; dichloromethane; dimethyl sulfoxide; isopropyl alcohol; toluene;
DOI:10.1039/c3ob40692j