Fehling's reagent (A)

Base Information

• Chemical Name: Fehling's reagent (A)
• CAS No.: 7758-98-7
• Molecular Formula: CuSO4
• Molecular Weight: 159.60
• Hs Code.: 2833 25 00
• Mol file: 7758-98-7.mol

Synonyms:Fehling's reagent (A);Copper(II) sulfate, p.a., 97.0%;QTL1_000026;Copper(II) sulfate, ReagentPlus(R), >=99%;Copper(II) sulfate, JIS first grade, >=97.5%;Copper(II) sulfate, puriss. p.a., anhydrous, >=99.0% (RT);Copper(II) sulfate, anhydrous, powder, >=99.99% trace metals basis;Copper Sulfate, Pharmaceutical Secondary Standard;Certified Reference Material;Copper(II) sulfate, puriss., meets analytical specification of Ph. Eur., BP, USP, anhydrous, 99-100.5% (based on anhydrous substance)

Chemical Property of Fehling's reagent (A)

Chemical Property:

• Appearance/Colour: Bluish crystalline powder
• Vapor Pressure: 7.3 mm Hg ( 25 °C)
• Melting Point: 200 °C (dec.)(lit.)
• Boiling Point: 330oC at 760 mmHg
• PSA: 88.64000
• Density: 2.284
• LogP: -0.25970
• Storage Temp.: Store at +5°C to +30°C.
• Sensitive.: Hygroscopic
• Solubility.: H2O: soluble
• Water Solubility.: 203 g/L (20 ºC)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 160.896977
• Heavy Atom Count: 6
• Complexity: 81.3

Purity/Quality:

99.0% ^*data from raw suppliers

Copper(II) sulfate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N,Xi
• Hazard Codes: Xn,N,Xi
• Statements: 36/38-50/53-22-51/53-36/37/38
• Safety Statements: 24/25-36-60-61-22-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: OS(=O)(=O)O.[Cu]
• Aquaculture: Copper sulfate is widely used in aquaculture to treat infectious diseases caused by parasitic protozoa and crustaceans, such as Cryptobia sp., Trichodina sp., Chilodonella sp., and Sinergasilus sp.
• Umbilical Granuloma Treatment: Copper sulfate (CuSO4) is utilized for chemical cauterization in the treatment of umbilical granuloma, although it can cause superficial skin burns. An alternative treatment using table salt (NaCl) osmotically dehydrates granulation tissue, leading to necrosis.
• Historical Uses and Toxic Properties: Copper sulfate has been historically used for wound debridement due to its antiseptic properties and as an emetic agent in intoxications. It is found in certain dental cements and intrauterine devices. While poisoning is rare, it can lead to gastrointestinal disease, with oral ingestion being the most common route.
• Marine Parasite Control: Copper sulfate is employed to combat marine parasites like Cryptocaryon irritans, a harmful parasite in mariculture.
• Biotoxicity Studies: Copper sulfate is studied as a biotoxin, particularly its impact on seed germination and microbial growth inhibition. It has shown little impact on seed germination rates but is effective against oomycete pathogens like Phytophthora and Halophytophthora, suggesting its use as an antimicrobial treatment.
• Essential Trace Element: Copper (Cu) in the form of copper sulfate is essential for living organisms' efficient functioning. It acts as a potent oxidant and has a history of agricultural use as a fungicide, bactericide, and pesticide, particularly against smaller animals like snails. The toxicity of copper depends on factors such as physical form, dosage, and exposure period, with potential effects on embryos and growth rates.

Refernces

Cleavage of acetals promoted by copper (II) sulphate adsorbed on silica gel

10.1080/00397919508011371

The research focuses on the efficient removal of protective groups, specifically cyclic acetals and tetrahydropyranyl ethers, from carbonyl and hydroxyl compounds. The purpose of this study was to develop a mild method for the cleavage of these protective groups using copper (II) sulfate supported on silica gel in organic solvents. The conclusions drawn from the research indicate that the method is effective for the removal of cycloacetals and tetrahydropyranyl groups in low polarity solvents such as dichloromethane, chloroform, or benzene, and that it allows for chemoselective removal without affecting cyanohydrin and ester functions or primary and sterically hindered secondary alcohols. The chemicals used in the process include various substrates like cycloacetals and tetrahydropyranyl ethers, solvents such as benzene, dichloromethane, and chloroform, and reagents like copper (II) sulfate, silica gel, p-toluenesulfonic acid, and pyridinium p-toluenesulfonate.

Synthesis of monofunctional curcumin derivatives, clicked curcumin dimer, and a PAMAM dendrimer curcumin conjugate for therapeutic applications

10.1021/ol702370m

The research describes the synthesis of monofunctional curcumin derivatives, a "clicked" curcumin dimer, and a PAMAM dendrimer-curcumin conjugate for therapeutic applications. The purpose of this study was to overcome the poor water and plasma solubility of curcumin, a bioactive compound found in turmeric, which possesses antioxidant, anticancer, anti-inflammatory, and anti-Alzheimer's disease properties. The researchers developed a synthetic methodology to produce curcumin conjugates with water-soluble polymers and targeting proteins, potentially enhancing curcumin's therapeutic efficacy. Key chemicals used in the process include curcumin, glutaric anhydride, amino-PEG azide, 1,3-dicyclohexylcarbodiimide (DCC), propargyl bromide, K2CO3, and copper(II) sulfate with sodium ascorbate for the "click" reaction. The study concluded that the monofunctional curcumin derivatives retained biological activity, efficiently labeled and dissolved amyloid fibrils, and the curcumin dimer selectively destroyed human neurotumor cells, making it a promising drug candidate. The conjugates were also expected to exhibit the EPR effect, enhancing their potential therapeutic applications.